Oxidative pathways of arachidonic acid as targets for regulation of platelet activation

Publication date: Available online 18 October 2019Source: Prostaglandins & Other Lipid MediatorsAuthor(s): Andrés Trostchansky, Rodrigo Moore-Carrasco, Eduardo FuentesAbstractPlatelet activation plays an important role in acute and chronic cardiovascular disease states. Multiple pathways contribute to platelet activation including those dependent upon arachidonic acid. Arachidonic acid is released from the platelet membrane by phospholipase A2 action and is then metabolized in the cytosol by specific arachidonic acid oxidation enzymes including prostaglandin H synthase, 12-lipoxygenase, and cytochrome P450 to produce pro- and anti-inflammatory eicosanoids. This review aims to analyze the role of arachidonic acid oxidation on platelet activation, the enzymes that use it as a substrate associated as novel therapeutics target for antiplatelet drugs.
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research