Protective Effect of Buyang Huanwu Decoction on Neurovascular Unit in Alzheimer's Disease Cell Model via Inflammation and RAGE/LRP1 Pathway.

CONCLUSIONS BYHWD regulates Aß metabolism via the RAGE/LRP1 pathway, inhibits vascular endothelial inflammation induced by ICAM-1 and VCAM-1 via the NF-kappaBP65 pathway, and promotes morphological changes induced by Aß-induced brain microvascular endothelial cell damage. PMID: 31625533 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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DiscussionOur findings raise the possibility that APOE ε4 carrier status may modify the relationship between postoperative day 2 CRP levels and postoperative delirium.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: Available online 20 November 2019Source: Alzheimer's &DementiaAuthor(s): Hector M. González, Wassim Tarraf, Myriam Fornage, Kevin A. González, Albert Chai, Marston Youngblood, Maria de los Angeles Abreu, Donglin Zeng, Sonia Thomas, Gregory A. Talavera, Linda C. Gallo, Robert Kaplan, Martha L. Daviglus, Neil SchneidermanAbstractHispanics/Latinos are the largest ethnic/racial group in the United States and at high risk for Alzheimer's disease and related dementia (ADRD). Yet, ADRD among diverse Latinos is poorly understood and disparately understudied or unstudied compared to other ethnic/...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
DiscussionEarly “subtle cognitive decline” among Aβ+ CN on a sensitive cognitive composite demonstrably increases risk for imminent clinical disease progression and functional impairment.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
  Look at Kimberly’s dramatic transformation in appearance after just two months on the Wheat Belly lifestyle: the lateral dimensions of her face are reduced, her cheeks are no longer bloated, the around-the-eye swelling is gone and her eyes are bigger. She lost “only” 20 pounds but, judging by the “deflation” of her facial features, it looks more like 100 pounds—this is what happens when you reverse the body-wide inflammation caused by wheat/grain consumption. “I didn’t recognize myself! This side-by-side spoke volumes! I’ve lost about 20 pounds so far. I was...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open Inflammation Weight Loss wheat belly Source Type: blogs
Publication date: Available online 20 November 2019Source: Toxicology ReportsAuthor(s): Kader Cetin Cakmak, ─░lhami GülçinAbstractUsnic acid, as active dibenzofuran derivative, isolated and characterized from some lichen species. The aim of manuscript was to evaluate antioxidant, anticholinergic and antidiabetic potentials of usnic acid as an important natural product. Antioxidant profile of usnic acid determined by eight distinguishes bioanalytical antioxidant methods. The antioxidative properties of usnic acid were performed using by several bioanalytical assays. 1,1-diphenyl-2-picrylhydrazyl (DPPH·), ...
Source: Toxicology Reports - Category: Toxicology Source Type: research
No abstract available
Source: Neurology Today - Category: Neurology Tags: In The Pipeline Source Type: research
No abstract available
Source: Neurology Today - Category: Neurology Tags: At The Bench Source Type: research
(Oxford University Press USA) A new paper in the Journal of Neuropathology&Experimental Neurology finds a gene that may help explain a large part of the genetic risk for developing Alzheimer disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Nature Reviews Neurology, Published online: 21 November 2019; doi:10.1038/s41582-019-0293-yA single case from Columbia provides insights into Alzheimer disease resistance
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
This study investigated the functional brain connectome architecture in patients with Posterior Cortical Atrophy (PCA). Eighteen PCA patients and 29 age- and sex- matched healthy controls were consecutively recruited in a specialized referral center. Participants underwent neurologic examination, cerebrospinal fluid (CSF) examination for Alzheimer's disease (AD) biomarkers, cognitive assessment, and brain MRI. For a smaller subset of participants, FDG-PET examination was available. We assessed topological brain network properties and regional functional connectivity as well as intra- and inter-hemispheric connectivity...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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