Carcinoma Cuniculatum of the Lower Leg: A Case Report and Proposed Diagnostic Criteria

Abstract: Carcinoma cuniculatum is an infrequent variant of squamous cell carcinoma described for the first time by Ian Aird in 1954. Since then, multiple reports of cutaneous carcinoma cuniculatum have been published at various sites, including palms, soles, buttocks, and lower legs, but most of them did not match to original description. In the current study, we report a unique case of a 69-year-old woman with carcinoma cuniculatum arising in the calf. Moreover, we update the histopathological criteria of cutaneous carcinoma cuniculatum by combining the literature descriptions and the experiences from the current case.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research

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ABSTRACT Carcinoma cuniculatum (CC), a rare variant of oral squamous cell carcinoma, presents well-differentiated neoplastic epithelial cells infiltrating the underlying submucosal or bone tissues, forming the so-called "rabbit burrows" filled with keratin. A 67-year-old female patient was referred complaining of a painless tumoral mass in the left mandibular body, with several months of evolution. Previous history indicated extraction of the teeth #37 and #38 and diagnosis of chronic suppurative osteomyelitis. A deep incisional biopsy revealed CC. Due to its microscopic features, suggesting an inflammatory or re...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
CONCLUSIONPrognostic factors such as perineural invasion, lymph node metastasis and distant metastasis were uncommon occurrences which may have practical implications on treatment. Further studies are needed to substantiate our findings.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Abstract We aimed to immunohistochemically characterize the pattern of expression of epithelial markers in rare head and neck squamous cell carcinoma (HNSCC) variants: carcinoma cuniculatum (CC) and adenosquamous carcinoma (ASC). We also present an additional variant of HNSCC with concomitant basaloid and squamous components that has overlapping morphological features with odontogenic and non-odontogenic tumors, which we termed basalo-squamous carcinoma (BSC). The selected markers included CK5/6, p40, CK19, BerEP4, p16 and SOX10. All tumors were CK5/6 and p40 positive. CK19 and BerEP4 were positive in BSC and foca...
Source: Acta Histochemica - Category: Biochemistry Authors: Tags: Acta Histochem Source Type: research
Oral verrucous carcinoma is a rare and special form of well-differentiated squamous cell carcinoma with specific clinical and histological features. This tumor grows slowly and locally and is invasive in nature and unlikely to metastasize. It appears as a painless, thick white plaque resembling a cauliflower. The most common sites of oral mucosal involvement include the buccal mucosa, followed by the mandibular alveolar crest, gingiva, and tongue. Surgery has been the first choice of treatment for these lesions, and radiotherapy is controversial; however, surgery combined with radiotherapy is the next most preferable treat...
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma (SCC). It is described as a low grade, slow growing, locally infiltrative neoplasm that accounts for 3-8% of all penile SCC. A 64-year-old uncircumcised, paraplegic male presented with a 2-month history of an asymptomatic, enlarging penile lesion with episodic spontaneous bleeding. The patient had been confined to a wheelchair for 15 years due to transverse myelitis and was wearing a diaper secondary to overflow urinary incontinence.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Conclusion: Verrucous carcinoma is a low grade variant of squamous cell carcinoma and the clinical features of both are very similar. The treatment of both differs widely; we fail to diagnose it correctly. This study correlates the clinic-pathologic features of oral verrucous carcinoma by means of statistically analyzing the varied clinical features and pathological impressions. This is helpful in eliminating the diagnostic dilemma and thus channelizing the data to present a clear treatment planning.
Source: Journal of Oral and Maxillofacial Pathology - Category: ENT & OMF Authors: Source Type: research
ConclusionCC shows an indolent clinical behavior, with a low recurrence rate after radical surgery. The diagnosis of this rare tumor is typically made after surgery. An aggressive approach is required with curative intents.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
CONCLUSION: CC shows an indolent clinical behavior, with a low recurrence rate after radical surgery. The diagnosis of this rare tumor is typically made after surgery. An aggressive approach is required with curative intents. PMID: 31472995 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - Category: Pathology Authors: Tags: Pathol Res Pract Source Type: research
ConclusionThis study reflects the lack of standardized diagnostic criteria and terminology for lesions in the PVL spectrum. We recommend that standardized criteria and terminology be proposed and established by an expert panel position paper, which would assist pathologists and clinicians to uniformly diagnose and manage PVL spectrum lesions more effectively.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: July 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 1Author(s): Dr. Liya Davidova, Dr. Rekha Reddy, Dr. Sarah Fitzpatrick, Dr. Indraneel Bhattacharyya, Dr. Donald Cohen, Dr. Mohammed IslamIntroductionStudies on inflammatory response to oral squamous cell carcinoma (OSCC) generally do not include verrucous carcinoma (VC), which typically carries a far better prognosis. While high CD8 expression is associated with favorable outcome in head and neck cancers, the role of CD4+ lymphocytes remains controversial. B cell involvement has been suggested to enhance T ce...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
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