Outbreaks of serious pneumococcal disease in closed settings in the conjugate vaccines era, 2010-2018: a systematic review to inform national guidance in the UK

Outbreaks of severe pneumococcal disease occur sporadically and can affect large numbers of individuals, although they are less frequent compared to the pre-antibiotic era.1 The responsible pathogen, Streptococcus pneumoniae, is a Gram-positive bacterium that commonly colonises the nasopharyngeal tract, especially in young children. Occasionally, however, it can invade locally to cause mucosal infections including sinusitis, otitis media or pneumonia. Rarely, invasion of the bloodstream can lead to more serious infections, including septicaemia and meningitis.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research

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Publication date: Available online 15 November 2019Source: Trends in Food Science &TechnologyAuthor(s): Heera Jayan, Hongbin Pu, Da-Wen SunAbstractBackgroundMicrobial contamination is an increasing concern in the food industry. In order to understand the effect of microorganisms, the study of their characteristics and behavior in various platforms is of prime importance. Over the years, time-consuming and labor-intensive, culture-based enumeration techniques have become obsolete for real-time applications, and increasing concerns on foodborne outbreaks necessitate rapid, on-site and sensitive methods for the detection ...
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
The objective of this study was to evaluate the effectiveness of pulsed light (PL) treatment, a novel antimicrobial (LAPEN) wash and combinations thereof in inactivating Salmonella on stem scars of cherry tomato. The treatment effects on background microbiota and sensory quality was also investigated while in storage for 21 days at 10 °C. Three serotypes of Salmonella enterica were chosen to prepare inoculum for the current investigation for their link with tomato and produce outbreaks. Stem scars of tomato were spot inoculated before being treated with PL (1–63 J/cm2), LAPEN sanitizer (2 min) or combinatio...
Source: Food Control - Category: Food Science Source Type: research
Authors: Gatti M, Raschi E, De Ponti F Abstract BACKGROUND: The management of Klebsiella pneumoniae carbapenemase producing (KPC) infections represents a major challenge. Several safety and efficacy concerns are shared by available antibiotics used in KPC infections, leading to the occurrence of serious adverse drug reactions (ADRs), with ceftazidime-avibactam possibly showing a more favourable risk-benefit profile. We investigated the potential impact of resistance on ADR reports in countries with different prevalence of KPC isolates (Italy vs. United Kingdom [UK]), and described safety profile of newer and older ...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
This study not only determined the primary reason for the atypical IBD epidemic, but also remind us of the urgency for developing new vaccines against novel variant IBDV.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 15 November 2019Source: Veterinary MicrobiologyAuthor(s): Xian-Wei Wang, Mi Wang, Jing Zhan, Qian-Yu Liu, Lin-lin Fang, Chen-yao Zhao, Ping Jiang, Yu-Feng Li, Juan BaiAbstractSince late 2010, highly virulent PEDV G2-genotype strains have emerged globally extracting heavy losses on the pork industries of numerous countries. We investigated the characteristics of a field strain of PEDV (PEDV strain SH) isolated from a piglet with severe diarrhea on a farm in Shanghai China. Whole genome sequencing and analysis revealed that the SH strain belonged to subtype G2a and has a unique 12-aa deleti...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
In this study, we designed a simple strategy to achieve the co-delivery of a DNA vaccine and hydrophobic immune adjuvant (R848) and to enhance the adjuvanticity of R848 via the synergistic effect of GO and R848. Thiolated low-molecular-weight polyethylenimine (TPEI1.8) was crosslinked with 4-aminothiophenol-modified GO (TGO) via the formation of disulfide bonds. Thus, TGO with its assembled TPEI1.8 could not only load R848 but also electrostatically interact with the DNA vaccine. Owing to the reducibility of the disulfide bond in the cellular environment, the DNA vaccine could be readily released. This system can significa...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
Publication date: 16 November 2019Source: New Scientist, Volume 244, Issue 3256Author(s): Sam WongA vaccine based on a weakened version of the dengue virus was 80 per cent effective at preventing infections after one year in a trial of 20,000 children
Source: New Scientist - Category: Science Source Type: research
[WHO] Juba, 15 November 2019 - To mitigate the risk of cholera outbreak, the World Health Organization (WHO) in collaboration with the Ministry of Health, UNICEF and MedAir are immunizing 144 033 people against cholera in Renk, a county bordering Blue Nile state in Sudan.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[WHO] Children in 19 Northern states to be vaccinated in largescale campaign implemented by the Government of Nigeria and WHO with Gavi support
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
ConclusionOur study indicates RA-ILD among Blacks is predominantly a disease of elderly females with higher rates of GERD and CVD risk factors. Further studies are needed to identify the pathogenetic differences accounting for the gender distribution of RA-ILD among Black and White populations.Key Points•First study to assess ILD among predominantly Black RA patients.•The prevalence of RA-associated ILD was 6.36%, affecting mostly women in their sixth decade with seropositive disease.•COPD was the most common airway disease among non-RA-ILD Black population.•GERD was found in approximately one-third of ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
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