Natriuretic Peptides Attenuate Retinal Pathological Neovascularization Via Cyclic GMP Signaling in Pericytes and Astrocytes.

CONCLUSIONS: Protective pericyte effects of the ANP/GC-A/cGMP pathway counterregulate the initiation and progression of experimental proliferative retinopathy. Our observations indicate augmentation of endogenous pericyte ANP signaling as target for treatment of retinopathies associated with neovascularization.
PMID: 31619060 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 16, 2019 Category: Cardiology Authors: Spes KŠ, Hupp S, Werner F, Koch F, Völker K, Krebes L, Kämmerer U, Heinze KG, Braunger BM, Kuhn M Tags: Arterioscler Thromb Vasc Biol Source Type: research