The Role of Filaggrin in Atopic Dermatitis and Allergic Disease.
The Role of Filaggrin in Atopic Dermatitis and Allergic Disease. Ann Allergy Asthma Immunol. 2019 Oct 14;: Authors: Drislane C, Irvine AD PMID: 31622670 [PubMed - as supplied by publisher]
This article reviews the role of ILC in allergic skin diseases with a major focus on ILC2. While group 2 ILC are suggested to contribute to the pathogenesis of type 2 dominated inflammation as seen in atopic dermatitis, we have shown that lack of ILC2 in type 1 dominated contact hypersensitivity results in enhanced inflammation, suggesting a regulatory role of ILC2 in this context. We provide a concept of how ILC2 may influence context dependent the mutual counterbalance between type I and type II immune responses in allergic skin diseases.
Atopic dermatitis (AD) may impact health related quality of life (HRQOL) from a combination of signs, symptoms and comorbid anxiety, depression, and other atopic disease1, 2. Quality adjusted life years (QALYs) is a measure of health status and used in cost-effectiveness research. QALYs are estimated using health utility weights, where zero is the worst possible state of health and one is equivalent to perfect health. However, few studies examined the impact of AD on health utility scores.
PMID: 31698096 [PubMed - as supplied by publisher]
Atopic disorders are allergic conditions mediated by allergen-specific IgE. These diseases include asthma, rhinoconjunctivitis and atopic dermatitis (AD) among others. Susceptibility to their development depends on the interaction between genetic and environmental factors . The rapid increase in the prevalence of these disorders during the last 50 years points to environmental changes as the main responsible factors for the observed increment . Epidemiological data allowed to establish a negative correlation between the increase in allergies and the prevalence of certain infections, leading to the elaboration of the ...
Publication date: Available online 30 October 2019Source: Genes &DiseasesAuthor(s): Wei Wang, Tianhao Yao, Tianyi Zhang, Meiying Quan, Changyan Wang, Chen Wang, Lejia Zhang, Xiaoyan Tang, Shan Jian, Hongmei SongAbstractSelective immunoglobulin A deficiency (SIgAD) is considered to be the most common human primary immune-deficiency disease in the world. However, the incidence in China is obviously lower than Caucasian races. The definitionof SIgAD has changed over time with the progress of people's understanding. The scientific community did not reach a consensus on the definition until 1999. As a result, many previousl...
Patient is a 9-year-old male with a history of moderate/severe atopic dermatitis, allergic rhinitis and eosinophilic esophagitis (EoE). He initially presented to an outside gastroenterologist at 3 years of age due to poor growth and picky eating. He had an endoscopy performed, which demonstrated esophageal eosinophilia. At the time of EoE diagnosis, patient was without IgE mediated food allergies, specifically tolerating dairy products regularly without symptoms. His initial management of eosinophilic esophagitis included the 4-food elimination diet.
Allergic contact dermatitis is a common inflammatory skin disease presenting with pruritus and eczematous lesions following skin contact to offending agents.
This case vignette describes systemic contact dermatitis resulting from dental amalgam inducing a delayed hypersensitivity reaction to mercury. It emphasizes the need for combination of patch and lymphocyte transformation tests for elusive etiologies for persistent symptoms of contact dermatitis.
Severe allergic conjunctivitis (AC) can lead to debilitating ocular symptoms with a risk of vision loss. Driven primarily by conjunctival mast cells and eosinophils, AC is also commonly associated with atopic conditions such as atopic dermatitis, asthma, and rhinitis. AC can present in various forms including atopic keratoconjunctivitis (AKC), vernal keratoconjunctivitis (VKC), and perennial allergic conjunctivitis (PAC). AK002 is an anti-Siglec-8 antibody that selectively depletes eosinophils and inhibits mast cells.
The search for criteria for identification of exogenous versus endogenous atopic dermatitis (AD) is of great importance for personalized treatment.