Viruses, Vol. 11, Pages 964: Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine
Viruses, Vol. 11, Pages 964: Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine
Viruses doi: 10.3390/v11100964
Authors:
Andersen
Krpina
Ianevski
Shtaida
Jo
Yang
Koit
Tenson
Hukkanen
Anthonsen
Bjoras
Evander
Windisch
Zusinaite
Kainov
Viruses are the major causes of acute and chronic infectious diseases in the world. According to the World Health Organization, there is an urgent need for better control of viral diseases. Repurposing existing antiviral agents from one viral disease to another could play a pivotal role in this process. Here, we identified novel activities of obatoclax and emetine against herpes simplex virus type 2 (HSV-2), echovirus 1 (EV1), human metapneumovirus (HMPV) and Rift Valley fever virus (RVFV) in cell cultures. Moreover, we demonstrated novel activities of emetine against influenza A virus (FLUAV), niclosamide against HSV-2, brequinar against human immunodeficiency virus 1 (HIV-1), and homoharringtonine against EV1. Our findings may expand the spectrum of indications of these safe-in-man agents and reinforce the arsenal of available antiviral therapeutics pending the results of further in vitro and in vivo tests.
Source: Viruses - Category: Virology Authors: Andersen Krpina Ianevski Shtaida Jo Yang Koit Tenson Hukkanen Anthonsen Bjoras Evander Windisch Zusinaite Kainov Tags: Article Source Type: research
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