A single amino acid substitution (H451Y) in Leishmania calcium-dependent kinase SCAMK confers high tolerance and resistance to antimony

ConclusionsThese results establish thatLeishmania SCAMK is a new central hub of antimony ’s mode of action and resistance development, and uncover the importance of drug tolerance mutations in the evolution of parasite drug resistance.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research