Antibiotic choice in UK general practice: rates and drivers of potentially inappropriate antibiotic prescribing

ConclusionsAntibiotic prescribing did not always align with prescribing guidelines, especially for URTIs and otitis externa. Future interventions might target optimizing amoxicillin use in primary care.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research

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Authors: Montemurro F, Nuzzolese I, Ponzone R Abstract Introduction: The administration of chemotherapy before (neoadjuvant), rather than after surgery (adjuvant) in early breast cancer has been considered an optional strategy for patients with operable breast cancer. We reviewed this concept considering recent results in the field.Areas covered: Herein, the authors cover neoadjuvant chemotherapy with or without biologics in triple-negative and HER2-positive operable breast cancer with a focus on rates of complete pathological remission (pCR) in the breast and axilla. The impact of the CREATE X and KATERINE randomi...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Survival of patients with advanced ovarian cancer continues to increase, despite concerns that increased use of neoadjuvant chemotherapy (NAC) could have a negative impact on outcomes.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Conclusion: EATL with brain metastasis is a very rare occurrence with dismal prognosis. PMID: 32233276 [PubMed - in process]
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
We present 3 cases of PRES of whom 2 are presumably caused by oxaliplatin and one by regorafenib. We discuss in this article the 3 cases individually and we summarize in the discussion the proposed theories in the literature of possible pathophysiological mechanisms. Our main goal of this article is to increase awareness among physicians when they are confronted with patients on chemotherapy who present with (sub)acute encephalopathy. PMID: 32233271 [PubMed - in process]
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Authors: Choi YH, Lee SH, You MS, Shin BS, Paik WH, Ryu JK, Kim YT, Kwon W, Jang JY, Kim SW Abstract Background/Aims: There has been growing evidence on the utility of neoadjuvant FOLFIRINOX in borderline resectable (BR) or locally advanced (LA) pancreatic cancer. However, factors predicting survival in these patients remain to be identified, and we aimed to identify these prognostic factors. Methods: Between January 2013 and April 2017, patients with BR or LA pancreatic cancer who received FOLFIRINOX as their initial treatment were identified. Demographic data and clinical outcomes, including the chemotherapy ...
Source: Gut and Liver - Category: Gastroenterology Tags: Gut Liver Source Type: research
By CHADI NABHAN MD, MBA, FACP One harsh Chicago winter, I remember calling a patient to cancel his appointment because we had deemed it too risky for patients to come in for routine visits—a major snowstorm made us rethink all non-essential appointments. Mr. Z was scheduled for his 3-month follow-up for an aggressive brain lymphoma that was diagnosed the prior year, during which he endured several rounds of intense chemotherapy. His discontent in hearing that his appointment was canceled was palpable; he confessed that he was very much looking forward to the visit so that he could greet the nurses, front-desk sta...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: COVID-19 Hospitals Medical Practice Physicians Chadi Nabhan Clinical Trials coronavirus drug dosing Oncology Pandemic Source Type: blogs
Authors: Suzuki T, Tetsuka S, Ogawa T, Hashimoto R, Okada S, Kato H Abstract VZV encephalitis in the absence of vasculopathy may rarely occur in association with herpes zoster. We herein report the case of a 67-year-old woman with non-Hodgkin' s lymphoma undergoing chemotherapy who presented with an acute alteration in consciousness. Magnetic resonance imaging of the brain revealed multiple and nonspecific lesions of hyperintensity with mild edema in the cortex and subcortex. She was treated with intravenous acyclovir. However, two days after admission, the patient died and was diagnosed with VZV encephalitis. This...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC00472C, CommunicationSourav Acharya, Subhashis Ghosh , Moumita Maji, Ajmal Roshan Unniram Parambil, Sandeep Singh, Arindam Mukherjee Cancer stem cell (CSCs) contributes to the poor therapeutic efficacy and cancer relapse which limits the application of conventional chemotherapy. Herein, we have reported six Ru complexes of mesalazine based... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
The trial evaluating the first-line treatment of pembrolizumab in patients with microsatellite instability-high or mismatch repair deficient unresectable or metastatic colorectal cancer demonstrated improved PFS compared with chemotherapy.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
BOSTON (CBS) — Julie Tolek remembers the exact minute her life changed forever: June 26, 2019. It was eight in the morning when she was diagnosed with breast cancer. “I thought I was in a dream. Nightmare, I guess, is a better description,” Tolek recalled. “I couldn’t say the word. It couldn’t be my life.” The diagnosis: stage two grade two invasive ductal carcinoma — an aggressively growing cancer. “I chose to have a double mastectomy even though my cancer was only in one breast. I decided I wanted to do everything in my power to not have to go through this again,&rdqu...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated Local Breast Cancer Coronavirus Juli McDonald Mammograms Source Type: news
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