Non-covalent glycosylated gold nanoparticles/peptides nanovaccine as potential cancer vaccines

Publication date: Available online 17 October 2019Source: Chinese Chemical LettersAuthor(s): Liming Zeng, Zonglang Liao, Wenwei Li, Qijuan Yuan, Peng Wu, Zhipeng Gu, Zhongqiu Liu, Guochao LiaoAbstractHerein, we firstly developed a non-covalent glycosylated gold nanoparticles/peptides nanovaccine which is assembled by β-cyclodextrin (β-CD) based host-guest recognitions. This nanovaccine can generate significant titers of antibodies and improve the therapeutic effect against melanoma, suggesting the immunogenicity of peptide antigens can be improved by loading with this carrier. The novel vaccine carrier provides a platform for the transport of various antigens especially T cell-independent antigens.Graphical abstractNon-covalent glycosylated gold nanoparticles/peptides nanovaccine has been firstly developed via β-cyclodextrin (β-CD) based host-guest assembled and indicated great potential for cancer therapy
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research