Gold nanorods with a noncovalently tailorable surface for multi-modality image-guided chemo-photothermal cancer therapy

Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC07131H, CommunicationLudan Yue, Chen Sun, Qian Cheng, Yuanfu Ding, Jianwen Wei, Ruibing Wang Cucurbit[7]uril functionalized Au nanorods allowed noncovalently tailorable surface modification for image-guided, targeted chemo-photothermal cancer therapyin vitro andin vivo. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research

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Publication date: 25 December 2019Source: Journal of Industrial and Engineering Chemistry, Volume 80Author(s): Jung Hwan Park, Jeong-Kee Yoon, Yu-Jin Kim, Tae-Jin Lee, Gun-Jae Jeong, Dong-Ik Kim, Suk Ho BhangAbstractDue to their heat-generating property based on exogenous energy irradiation, reduced graphene oxide particles (RGOs) have been widely used for photothermal cancer therapy. They show high absorbance for the near-infrared wavelength that is suitable for in vivo experimentation. However, enhancing the tumor-targeting efficiency and avoiding the self-aggregation of RGO to maximize the photothermal effect remain cha...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
In this study, pH-responsive nanogels are developed by forming benzoic imine bonds between hyaluronic acid-graft-methoxy poly(ethylene glycol)-diethylenetriamine (HA-PEG-Diet) copolymers and terephthalaldehyde (TPA) crosslinkers for dual-targeting protein delivery. Cytochrome C (CC), a protein drug, could be facilely encapsulated into the nanogels with a high loading efficiency. Under a physiological environment, these nanogels exhibit excellent stability due to the presence of hydrophobic cores. However, under an acidic tumor microenvironment, the nanogels can undergo pH-induced cleavage of benzoic imines that initiates s...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Abstract The intestine serves mainly as a place for digestion and absorption and functions as an immune and endocrine organ. Intestinal stem cells (ISCs) play critical roles in the maintenance of intestinal homeostasis and regeneration, and a complex of signaling pathways is involved in these processes. The Notch signaling pathway is induced via distinct cell-to-cell connections, which are activated through the binding of the Notch ligand on the surface of niche cells to the Notch receptor on ISCs. Numerous studies have shown the central importance of Notch signaling in the proliferation and differentiation of ISC...
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
AbstractThe paradoxical pro-tumorigenic function of plasminogen activator inhibitor 1 (PAI-1, aka Serpin E1) in cancer progression and metastasis has been the subject of an abundant scientific literature that has pointed to a pro-angiogenic role, a growth and migration stimulatory function, and an anti-apoptotic activity, all directed toward promoting tumor growth, cancer cell survival, and metastasis. With uPA, PAI-1 is among the most reliable biomarkers and prognosticators in many cancer types. More recently, a novel pro-tumorigenic function of PAI-1 in cancer-related inflammation has been demonstrated. These multifacete...
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
Abstract Hyaluronic acid functionalized mesoporous hollow alumina nanoparticles (HMHA) were used as a tumor-targeted delivery carrier for liver cancer therapy. Paclitaxel (PAC) incorporated in the carrier by the adsorption method was analyzed by X-ray diffraction and differential scanning calorimetry. PAC was found to be in an amorphous state. The hyaluronic acid coated on the surface of mesoporous hollow alumina nanoparticles (MHA) regulated the drug release rate and the loaded samples obtained a sustained drug release. In vitro experiments demonstrated that paclitaxel-hyaluronic acid functionalized mesoporous ho...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 14 November 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Zhen-Lei Liu, Qing-Yang Jia, Xiao-Dong Li, Shu-Ping Li, Jian Shen, Jun Lin, Dong-Xiang LiAbstractA hollow mesoporous microspheres of hydroxyapatite-Au containing the anticancer agent of methotrexate (hmHAp-Au/MTX) were prepared here. Firstly, biocompatible hydroxyapatite nanoparticles (NPs) with a hollow core and mesoporous shell structure (hmHAp) were synthesized by a template method. Secondly, Au NPs were successfully conjugated onto the surface of hmHAp through the electrostatic attractio...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Publication date: Available online 13 November 2019Source: Life SciencesAuthor(s): Nidhi Korgaonkar, Khushwant S. YadavAbstractCancer has become a key healthcare problem worldwide. The background of cancer research has brought the advent of cross-disciplinary collaborations that has enabled us to get an idea of the disease mechanisms at spatial and temporal scales. Understanding the combination of biology and physics of cancer presents a promising field of research with apprehensions in better clarity over both cellular and molecular mechanisms impacting cancer therapy. Investigation of cancer biology has provided a wealth...
Source: Life Sciences - Category: Biology Source Type: research
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) occurs in ∼70% of human cancers, and STAT3 is regarded as one of the most promising targets for cancer therapy. However, specific direct STAT3 inhibitors remain to be developed. Oridonin is an ent-kaurane plant-derived diterpenoid with anti-cancer and anti-inflammatory activities. Here, using an array of cell-based and biochemical approaches, including cell proliferation and apoptosis assays, pulldown and reporter gene assays, site-directed mutagenesis, and molecular dynamics analyses, we report that a thiazole-derived oridonin analog...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Signal Transduction Source Type: research
Nammour Oral complications of cancer therapy, such as oral dryness, dysphagia, and taste alteration, are associated with a negative impact in the quality of life of the patients. Few supportive care measures are available for such complications. This case series reveals the effectiveness of the photobiomodulation (PBM) therapy when used in a specific protocol and parameters, in the management of oral complications related to cancer therapy. Dysphagia was measured using the functional outcome swallowing scale for staging oropharyngeal dysphagia (FOSS). Oral mucositis was measured according to the National Cancer Institu...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Case Report Source Type: research
Authors: Flores-Pérez JA, de la Rosa Oliva F, Argenes Y, Meneses-Garcia A Abstract Cancer is a complex group of diseases where different signaling pathways have been found to be deregulated, mainly related to cell proliferation, angiogenesis, metastasis, evasion of apoptosis and insensitivity to anti-growth sings among others. Diet plays a fundamental role in the treatment of the oncological patients, we must be aware that food can interact with certain types of cancer therapy. On the other hand, cancer therapies sometimes affect the patient's sense of smell, taste, appetite, gastric capacity or nutrient abs...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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