Complement component C1q is produced by isolated articular chondrocytes

Inflammation and innate immune responses may contribute to development and progression of Osteoarthritis (OA). Chondrocytes are the sole cell type of the articular cartilage and produce extracellular-matrix molecules. How inflammatory mediators reach chondrocytes is incompletely understood. Previous studies have shown that chondrocytes express mRNA encoding complement proteins such as C1q, suggesting local protein production, which has not been demonstrated conclusively. The aim of this study is to explore C1q production at the protein level by chondrocytes.

Source: Osteoarthritis and Cartilage - October 17, 2019 Category: Rheumatology Authors: Rosalie Lubbers, Rosanne A. van Schaarenburg, Joanneke C. Kwekkeboom, Nivine E.W. Levarht, Aleida M. Bakker, Rachid Mahdad, Silvia Monteagudo, Chahrazad Cherifi, Rik J. Lories, Ren é E.M. Toes, Andreea Ioan-Facsinay, Leendert A. Trouw Source Type: research