Tau PET and Multimodal Brain Imaging in Patients at Risk for Chronic Traumatic Encephalopathy

ConclusionsMildly elevated tau-PET binding was observed in a subset of amyloid-negative patients at risk for CTE, in a distribution consistent with CTE pathology stages III-IV. FTP-PET may be useful as a biomarker of tau pathology in CTE but is unlikely to be sensitive to early disease stages.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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Title: Is Head Injury Causing Dementia? MRI Might ShowCategory: Health NewsCreated: 10/28/2019 12:00:00 AMLast Editorial Review: 10/29/2019 12:00:00 AM
Source: MedicineNet Alzheimer - Category: Geriatrics Source Type: news
Beta Amyloid Deposition Is Not Associated With Cognitive Impairment in Parkinson's Disease Tracy R. Melzer1,2,3†, Megan R. Stark1,2†, Ross J. Keenan1,4, Daniel J. Myall1, Michael R. MacAskill1,2, Toni L. Pitcher1,2,3, Leslie Livingston1,2, Sophie Grenfell1, Kyla-Louise Horne1,2, Bob N. Young1, Maddie J. Pascoe1, Mustafa M. Almuqbel1,2,4, Jian Wang5, Steven H. Marsh6, David H. Miller1,2,7, John C. Dalrymple-Alford1,2,3,8 and Tim J. Anderson1,2,3,9* 1New Zealand Brain Research Institute, Christchurch, New Zealand 2Department of Medicine, University of Otago, Christchurch, New Zealand 3Brain Rese...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
This study aimed to evaluate the impact of self-construal on neurocognitive functions in older adults. A total of 86 community-dwelling older adults 60 years and older were assessed with three common self-report measures of self-construal along individualism and collectivism (IC). A cognitive battery was administered to assess verbal and non-verbal fluency abilities. Latent profile analysis (LPA) was used to categorize individuals according to IC, and one-way analyses of covariance (ANCOVA), including relevant covariates (e.g., ethnicity, gender, linguistic abilities), were used to compare neurocognitive functions between ...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
MRC Laboratory of Molecular Biology researchers reveal atomic structures of the abnormal tau filaments associated with chronic traumatic encephalopathy, a head injury-associated neurodegenerative disease, differ in structure from those seen in Alzheimer’s disease.
Source: Medical Research Council General News - Category: Research Source Type: news
A dementia patient has worn the same clothes for eight months, has refused to take a shower, smells really bad; and, the nursing home won't do anything about it.Our reader Margaret wrote and asked for help.My brother is in a nursing home, with dementia and refuses to go in the shower. I complained 8 months ago and they said they cannot make him do anything he does not want to do.Today 8 months later the Doctor called saying my brother has the same clothes on and still will not take a shower and the smell is so bad.Well, what do they want me to do? He is combative with me, and now they are looking for my help.By Rita Jablon...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's Alzheimer's family alzheimer's story alzheimers care Alzheimers Dementia care of dementia patients help alzheimer's help with dementia care memory care nursing home Source Type: blogs
This study investigated the risk of dementia by type in patients with schizophrenia. METHODS: Data were collected from the Taiwanese National Health Insurance Database 2005 and analyzed using multivariate Cox proportional hazard regression models to determine the effect of schizophrenia on the dementia risk after adjusting for demographic characteristics, comorbidities, and medications. Fine and Gray's competing risk analysis was used to determine the risk of dementia, as death can act as a competing risk factor for dementia. RESULTS: We assessed 6040 schizophrenia patients and 24,160 propensity scale-matched contr...
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
Hot on the heels of headlines linking alcohol consumption with longer life comes new research that casts a much more sobering light on drinking. According to an analysis of more than 1 million people—the largest study of its kind to date—scientists say that heavy alcohol use is the biggest modifiable risk factor for dementia, especially early-onset forms of the disease. The findings, which are published in The Lancet Public Health, came as a shock to the researchers involved. “We hypothesized that alcohol would play some role, but I don’t think anyone expected the size of the effect to be so large,&...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime Research Source Type: news
In conclusion, we have developed an effective PILs strategy to deliver the AUF1 plasmid to a specific target, and this system may be useful for the development of new anti-aging drugs. Considering the Evidence for Vascular Amyloidosis as a Cause of Aging https://www.fightaging.org/archives/2017/11/considering-the-evidence-for-vascular-amyloidosis-as-a-cause-of-aging/ The balance of evidence for the aging of the cardiovascular system suggests the following view. It starts off in the blood vessels, with the accumulation of senescent cells and cross-links. Cross-links directly stiffen these tissues, while ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusions Stronger associations with shorter lag times indicate that head and/or brain injuries may also reflect the ongoing AD disease process.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Abstract A systematic review was conducted to identify risk factors associated with the onset and progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews were eligible for inclusion. Primary studies reporting on non-genetic risk factors associated with neuropathologically or clinically confirmed AD were considered. Eighty one systematic reviews reporting on AD onset and 12 reporting on progression satisfied the eligibility criteria. Four hundred and thirty-two relevant primary studies reporting on onset were identified; however, only those published between 2010 and 2012 (n=65) were i...
Source: Neurotoxicology - Category: Neurology Authors: Tags: Neurotoxicology Source Type: research
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