Deep lessons learned: Radiology, oncology, pathology, and computer science experts unite around artificial intelligence to strive for earlier pancreatic cancer diagnosis
Publication date: Available online 16 October 2019Source: Diagnostic and Interventional ImagingAuthor(s): E.M. Weisberg, L.C. Chu, S. Park, A.L. Yuille, K.W. Kinzler, B. Vogelstein, E.K. Fishman
Currently, an effective targeted therapy for pancreatitis is lacking. Hereditary pancreatitis (HP) is a heritable, autosomal-dominant disorder with recurrent acute pancreatitis (AP) progressing to chronic pancreatitis (CP) and a markedly increased risk of pancreatic cancer. In 1996, mutations in PRSS1 were linked to the development of HP. Here, we developed a mouse model by inserting a full-length human PRSS1R122H gene, the most commonly mutated gene in human HP, into mice. Expression of PRSS1R122H protein in the pancreas markedly increased stress signaling pathways and exacerbated AP. After the attack of AP, all PRSS1R122...
Condition: Pancreatic Adenocarcinoma Interventions: Drug: Gemcitabine; Drug: FOLFOX Sponsor: Assistance Publique - Hôpitaux de Paris Not yet recruiting
L-asparaginase and MEK inhibitor starve the tumour of vital nutrients and pathways which help cells multiply, Sanford Burnham Prebys Medical Discovery Institute showed in mice studies.
Publication date: 1 February 2020Source: Materials Chemistry and Physics, Volume 241Author(s): Nicoleta Badea, Mariela Madalina Craciun, Andreea Sofia Dragomir, Mihaela Balas, Anca Dinischiotu, Claudiu Nistor, Camelia Gavan, Daniela IonitaAbstractThe paper is concerned with obtaining nanosystems based on multiwalled carbon nanotubes (MWCNT), pemetrexed (Pm) and quercetin (Q) with antitumor action. MWCNT were contacted with ethanolic solutions of Pm/Q/Pm-Q, centrifuged and then filtered. The obtained nanosystems were structurally characterizedcaracterized by FTIR analysis. The physical stability of the nanosystem was assess...
(Sanford Burnham Prebys Medical Discovery Institute) Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a combination of two anti-cancer compounds that shrank pancreatic tumors in mice -- supporting the immediate evaluation of the drugs in a clinical trial. US Food and Drug Administration (FDA)-approved versions of the compounds are used today to treat certain leukemias and solid tumors, including melanoma. The study was published in Nature Cell Biology.
(University of North Carolina at Charlotte) In a review article, cancer biologists Pinku Mukherjee and Mukulika Bose argue that recent research suggests a mechanism that may implicate bacterial infections as important factors in epithelial cell cancers. The article points to microbial interactions that may alter the glycoprotein known as MUC1, triggering signaling pathways that cause cancer, including cancers of the colon, lungs, stomach, liver and pancreas.
VanLathem John R. MacKey Jean-Baptiste Bachet Magali Svrcek Jerome Cros Gemcitabine is still one of the standard chemotherapy regimens for pancreatic ductal adenocarcinoma (PDAC). Gemcitabine uptake into tumor cells is mainly through the human equilibrative nucleoside transport 1 (hENT1). It was therefore proposed as a potential predictive biomarker of gemcitabine efficacy but reports are conflicting, with an important heterogeneity in methods to assess hENT1 expression. A multicenter cohort of 471 patients with a resected PDAC was used to assess simultaneously the predictive value of the 2 best described hENT...
Individuals who have multiple close relatives with pancreatic cancer should undergo surveillance for pancreatic cancer, according to updated recommendations from the International Cancer of the Pancreas Screening (CAPS) Consortium.Reuters Health Information
This article reviews various hereditary pancreatic cancer syndromes, as well as pancreatic cancer screening recommendations, options, and limitations. PMID: 31730603 [PubMed - in process]
ConclusionsHigher burden of patient ‐reported outcome was associated with reduced OS among APC patients. The effect was prominent after adjusting for ECOG status.