We've completed the lab testing: "Groovy Bee" Collagen Peptides (hydrolyzed collagen) now available through the Health Ranger Store
(Natural News) For the last three years, we’ve had many requests for a collagen peptides product, but given that collagen peptides are animal-derived, this product category requires extra scrutiny using high-end laboratory analysis equipment. Because most animals are fed GMO feed that’s laced with glyphosate, the cancer-causing herbicide chemical used across modern agriculture, it is...
Publication date: Available online 1 June 2020Source: MethodsAuthor(s): Reyhaneh Manafi-Farid, Najme Karamzade-Ziarati, Reza Vali, Felix M. Mottaghy, Mohsen Beheshti
Publication date: Available online 2 June 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Dipanwita Das Mukherjee, N. Maruthi Kumar, Mukund P. Tantak, Satabdi Datta, Debabrata Ghosh Dastidar, Dalip Kumar, Gopal Chakrabarti
Th17 cells (producing IL-17) and Th9 cells (producing IL-9) exhibit functional plasticity, and their role in tumorigenicity is controversial. Th17/IL-17 and Th9/IL-9 exhibit critical, but often opposing, roles in tumor progression. In this issue of the JCI, Salazar et al. show that while IL-17 and IL-9 induced distinct but complementary molecular pathways, both cytokines also induced epithelial-mesenchymal transition (EMT) in lung cancer cells and promoted metastatic spreading. A key question before us now is whether IL-9 and IL-17 contribute to tumor progression in a sequential and stage-specific manner within the tumor microenvironment.
Emerging immune therapy, such as with the anti–programmed cell death–1 (anti–PD-1) monoclonal antibody nivolumab, has shown efficacy in tumor suppression. Patients with terminal cancer suffer from cancer pain as a result of bone metastasis and bone destruction, but how PD-1 blockade affects bone cancer pain remains unknown. Here, we report that mice lacking Pdcd1 (Pd1−/−) demonstrated remarkable protection against bone destruction induced by femoral inoculation of Lewis lung cancer cells. Compared with WT mice, Pd1−/− mice exhibited increased baseline pain sensitivity, but the deve...
In conclusion, Th9 and Th17 lymphocytes induce lung cancer cell EMT, thereby promoting migration and metastatic spreading and offering potentially novel therapeutic strategies.
Letter to the editor regarding "Potential for prevention: a cohort study of colonoscopies and removal of adenomas in a FIT-based colorectal cancer screening programme". Scand J Gastroenterol. 2020 Jun 01;:1-2 Authors: Thomsen MK, Støvring H, Mikkelsen EM PMID: 32479193 [PubMed - as supplied by publisher]
Publication date: Available online 1 June 2020Source: Sensors and Actuators B: ChemicalAuthor(s): Hyun Jeong Won, Akhmad Irhas Robby, Hee Sauk Jhon, Insik In, Ji Hyun Ryu, Sung Young Park
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ00879F, PaperVipan Kumar, Bharvi Sharma, Liang Gu, Ruvesh Pascal Pillay, Nosipho Cele, Paul Awolade, Parvesh Singh, Mandeep Kaur A series of 1H-1,2,3 triazole grafted tetrahydro- β-carboline-chalcone/ferrocenylchalcone conjugates were synthesized and invitro evaluated against Estrogen Responsive (MCF-7) and Triple Negative (MDA-MB-231) breast cancer cells. Comparative analysis revealed the improvement of... The content of this RSS Feed (c) The Royal Society of Chemistry
Publication date: Available online 1 June 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): N.M. Zholobak, A.B. Shcherbakov, O.S. Ivanova, V. Reukov, A.E. Baranchikov, V.K. Ivanov