Unexpected Role of CD8 T Cells in Accelerated Clearance of Salmonella enterica Serovar Typhimurium from H-2 Congenic mice [Microbial Immunity and Vaccines]

In this study, we further characterized the ability of H-2b, H-2k, and H-2u molecules to influence adaptive immunity to Salmonella in MHC congenic mice. By depleting different cell populations during infection, we unexpectedly found that CD8 T cells, in addition to CD4 T cells, play a major role in accelerated clearance of bacteria from H-2k congenic hosts. Our data suggest that CD8 T cells accelerate clearance in some MHC congenic mouse strains and could therefore represent an unexpected contributor to the protective efficacy of Salmonella vaccines outside the typical studies in C57BL/6 mice.

Source: Infection and Immunity - October 17, 2019 Category: Infectious Diseases Authors: Labuda, J. C., Depew, C. E., Pham, O. H., Benoun, J. M., Ramirez, N. A., McSorley, S. J. Tags: Microbial Immunity and Vaccines Source Type: research