Skeletal status assessed by quantitative ultrasound and dual-energy X-ray absorptiometry in children with inflammatory bowel disease: A 2-year prospective study

Publication date: Available online 17 October 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Katarzyna Bąk-Drabik, Piotr Adamczyk, Agata Chobot, Wojciech PluskiewiczSummaryPurposeTo assess the bone status in children with inflammatory bowel diseases (IBD) using quantitative ultrasound (QUS) measurement and dual-energy X-ray absorptiometry (DXA) at baseline and after two years of adequate treatment of the IBD and bone protection medication.MethodsSixteen children (six boys) with IBD, aged 13.4 ± 2.4 years, were examined at baseline and two years later. DXA was used to asses bone mineral density (BMD) and reference data were provided by the device's manufacturer (Hologic Explorer). QUS measurements were performed in patients and controls – 48 healthy children.ResultsMean Z-scores for TB- and s-BMD were significantly below zero for both, baseline and follow-up (−2.61 ± 0.99 and −2.48 ± 0.88 for TB, and −1.83 ± 1.33 and −1.61 ± 1.19 for s-BMD, respectively), and did not differ significantly, as well as mean Ad-SoS Z-score. The changes in time of TB Z-score and body weight Z-score correlated positively (r = 0.63; P 
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research

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Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Article: Gastroenterology: Inflammatory Bowel Disease Source Type: research
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Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Letters to the Editor Source Type: research
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Source: Metabolic Syndrome and Related Disorders - Category: Endocrinology Authors: Source Type: research
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In this study, the UC model of BABL/c mice were established by DSS [3.5% (w/v)], and HLJDD was given orally for treatment at the same time. During the experiment, the clinical symptoms of mice were scored by disease activity index (DAI). Besides, the effects of HLJDD on immune function, oxidative stress, colon NF-κB and Nrf2 signaling pathway, and intestinal mucosal barrier function in UC mice were also investigated. The results showed that HLJDD could alleviate body weight loss and DAI score of UC mice, inhibit colonic shortening and relieve colonic pathological damage, and reduce plasma and colon MPO levels. In add...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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