Roles of Phosphoinositides and Their binding Proteins in Parasitic Protozoa.

Roles of Phosphoinositides and Their binding Proteins in Parasitic Protozoa.
Trends Parasitol. 2019 Oct 12;:
Authors: Cernikova L, Faso C, Hehl AB
Abstract
Phosphoinositides (or phosphatidylinositol phosphates, PIPs) are low-abundance membrane phospholipids that act, in conjunction with their binding partners, as important constitutive signals defining biochemical organelle identity as well as membrane trafficking and signal transduction at eukaryotic cellular membranes. In this review, we present roles for PIP residues and PIP-binding proteins in endocytosis and autophagy in protist parasites such as Trypanosoma brucei, Toxoplasma gondii, Plasmodium falciparum, Entamoeba histolytica, and Giardia lamblia. Molecular parasitologists with an interest in comparative cell and molecular biology of membrane trafficking in protist lineages beyond the phylum Apicomplexa, along with cell and molecular biologists generally interested in the diversification of membrane trafficking in eukaryotes, will hopefully find this review to be a useful resource.
PMID: 31615721 [PubMed - as supplied by publisher]

Source: Trends in Parasitology - October 11, 2019 Category: Parasitology Authors: Cernikova L, Faso C, Hehl AB Tags: Trends Parasitol Source Type: research