Aberrant DNA methylation of PAX1, SOX1 and ZNF582 genes as potential biomarkers for esophageal squamous cell carcinoma

ConclusionThe methylation levels ofPAX1, SOX1 and ZNF582 genes were all higher in cancer tissues than in paired-adjacent and normal tissues, suggesting that detection of PAX1/SOX1/ZNF582 methylation status may serve as a promising biomarker for ESCC screening and diagnosis.Graphical abstractPyrosequencing is considered the gold standard for methylation detection. Using pyrosequencing to detect the DNA methylation statue of PAX1, SOX1 and ZNF582 in ESCC. The receiver operating characteristic curves showed that the detection of PAX1/SOX1/ZNF582 methylation status may serve as a promising biomarker for ESCC screening and diagnosis.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research