Changes in the prevalence of causative pathogens isolated from severe burn patients from 2012 to 2017
Publication date: Available online 18 October 2019Source: BurnsAuthor(s): Jin Ju Park, Yu Bin Seo, Young Kyun Choi, Dohern Kym, Jacob LeeAbstractInfection is the leading cause of mortality in severe burn patients, benefitting from periodic monitoring of changes in bacterial prevalence and antibiotic resistance trends. This single facility retrospective study evaluated blood culture results for patients hospitalized in the burn intensive care unit (BICU) from January 2012 to December 2017. A total of 969 samples from 420 patients were reviewed. Isolated pathogens were recorded by year and the number of days of hospitalization. Results showed that Acinetobacter baumanni was the most predominant isolated pathogen, followed closely by Pseudomonas aeruginosa, Klebsiella spp., and Enterococcus spp. Throughout this 6-year study, several significant trends were noted; Klebsiella species increased, while P. aeruginosa decreased. Staphylococcus aureus and Klebsiella species gradually increased, and P. aeruginosa doubled as the length of hospital stay increased to 22 days. Interestingly, as the length of the hospital stay increased, the proportion of Carbapenem-resistant Enterobacteriaceae (CRE) significantly increased up to 45.0% at 22 days (P = 0.003). Conversely, the proportion of Acinetobacter baumannii gradually decreased as the days hospitalized increased. Overall, the rate of multidrug-resistant (MDR) bacteremia found in burn patients was substantially higher than that ...
This article describes details of each stage of the mission and includes a discussion of key aspects of logistics and patient care posed by such evacuations. PMID: 31977424 [PubMed - in process]
Abstract A landmark report highlights clinician burnout and offers recommendations. PMID: 31977407 [PubMed - in process]
Publication date: Available online 24 January 2020Source: Microbial PathogenesisAuthor(s): Mani Divya, Marimuthu Govindarajan, Sivashanmugam Karthikeyan, Elumalai Preetham, Naiyf S. Alharbi, Shine Kadaikunnan, Jamal M. Khaled, Taghreed N. Almanaa, Baskaralingam VaseeharanAbstractβ-Glucan-binding protein (βGBP) is important for the rational expansion of molecular biology. Here, zinc oxide nanoparticle (ZnONP) was synthesized using βGBP from the crab Scylla serrata (Ss-βGBP-ZnONP). Ss-βGBP-ZnONP was observed as a 100 kDa band on sodium dodecyl sulfate polyacrylamide gel and characterized with UV&nd...
ConclusionsClHO at medium-low concentrations (300 or 500 mg/L) is a good antiseptic that can be used on wounds and mucous membranes for 5-10 minutes. Lower concentrations of ClHO, as well as of the other antiseptics studied, were less effective or more altered by the biofilm. ClHO at a concentration of 1500 mg/L is very effective in presence or absence of biofilm that can be used on healthy skin for 5 minutes.
This study suggests that intestinal inflammation and reduction of short chain fatty acids (SCFAs) caused by the imbalance of gut microbiota are crucial to the pathogenesis of T1DM.Graphical abstractIn this study, LEfSe multilevel species hierarchical tree directly reflects the differences of gut microbiota between control and T1DM rats at the Phylum-to-Family level, the result showed that the gut microbiome of T1DM rats changed significantly. The abundance of pathogenic bacteria associated with infection and inflammation in T1DM rats was up-regulated such as Ruminococcaceae, Shigella, Enterococcus, Streptococcus, Rothia an...
This study evaluated the association of concentrations of plasma penKid with death and risk of acute kidney injury (AKI) in severely ill burn patients.MethodsA prospective observational study in two centers with severely ill adult burn patients was conducted. The inclusion criteria were total body surface area (TBSA) burns>15%, with burn injury occurring
This study shows tunnel protected with calcium silicate board results in higher temperature and heat fluxes compare to non-protected tunnel and tunnel protected with magnesium oxides/Cement based spray. This indicates that passive fire protection system can alter the thermal conditions inside the tunnel in case of fire.
Patients with significant burn injuries likely have palliative care needs. We performed a systematic review of existing evidence concerning the palliative care needs of burn patients.
The term “moral injury” was first used in the context of war to describe soldiers' response to “perpetrating, failing to prevent, bearing witness to, or learning about acts that transgress deeply held moral beliefs and expectations.”1 Recently the concept of moral injury has been applied to healthcar e.2 Unlike burn out, moral injury does not connote feelings of cynicism, exhaustion or decreased productivity. Rather, healthcare providers feel deep-seated distress over situations or actions that, while seemingly appropriate, betray their sense of responsibility to patients.
Withdrawal of life-sustaining treatment (WLST) is a critically important time in the life of a patient and family and presents unique emotional pressure to all involved. The decision to redirect goals of inpatient care to focus on comfort is best supported by clear, evidence-based treatment. Use of an order set in the electronic health record (EHR) can facilitate best care for the dying patient.