Cancers, Vol. 11, Pages 1592: Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy

Cancers, Vol. 11, Pages 1592: Targeting Programmed Fusobacterium nucleatum Fap2 for Colorectal Cancer Therapy Cancers doi: 10.3390/cancers11101592 Authors: Kumar Ganesan Songhe Guo Sundaz Fayyaz Ge Zhang Baojun Xu Colorectal patients generally have the maximum counts of Fusobacterium nucleatum (F. nucleatum) in tumors and elevate colorectal adenomas and carcinomas, which show the lowest rate of human survival. Hence, F. nucleatum is a diagnostic marker of colorectal cancer (CRC). Studies demonstrated that targeting fusobacterial Fap2 or polysaccharide of the host epithelium may decrease fusobacteria count in the CRC. Attenuated F. nucleatum-Fap2 prevents transmembrane signals and inhibits tumorigenesis inducing mechanisms. Hence, in this review, we hypothesized that application of genetically programmed fusobacterium can be skillful and thus reduce fusobacterium in the CRC. Genetically programmed F. nucleatum is a promising antitumor strategy.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research