In Vivo Assessment of Tau Deposition in Alzheimer Disease and Assessing Its Relationship to Regional Brain Glucose Metabolism and Cognition

In this study, we investigated the relationship of cerebral tau deposition (18F-tau-AD-ML 104 PET/CT) with glucose metabolism (18F-FDG PET/CT) and cognitive function in patients with Alzheimer disease (AD). Patients and Methods Seventy subjects (Mini Mental State Examination [MMSE] score
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research

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ConclusionsThis study demonstrates biomarker-based MCI prognosis and supports its role in clinical decision-making in daily practice.ResumenObjetivoEl objetivo de este estudio fue investigar el rol y pronóstico de los biomarcadores de enfermedad de Alzheimer en pacientes con diagnóstico clínico de deterioro cognitivo leve (DCL) en una clínica de memoria de Latinoamérica.MétodoOchenta y nueve pacientes con DCL, 43 con demencia tipo Alzheimer y 18 controles normales apareados por edad, sexo y escolaridad fueron estudiados con un extenso protocolo demográfico, neurológic...
Source: Neurologia - Category: Neurology Source Type: research
CONCLUSIONS: Our results indicate that Alzheimer disease medication might contribute to a reduction of the LOS and the number of readmissions in PWD. PMID: 31722770 [PubMed - as supplied by publisher]
Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
CONCLUSION: We found no evidence that long-term exposure to work-related sleep loss had resulted in cognitive decline or early dementia symptoms in this sample of retired maritime pilots. PMID: 31726459 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
CONCLUSION: The AD8 is a brief and sensitive screening instrument that may facilitate earlier and more accurate AD diagnosis in a variety of care settings. PMID: 31725472 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
AbstractThe development of Alzheimer's disease (AD) has been strongly linked to the apolipoprotein E (APOE) polymorphism. A number studies have reported that theAPOEε4 allele is a genetic risk factor for developing AD, whereas theAPOEε2 andAPOEε3 alleles are considered to be neutral or even protective; however, there are conflicting data about these relationships in certain ethnic populations. Several meta-analyses have been performed to reduce the heterogeneity of results from different studies and estimate the real association in speci fic ethnicities. The aim of this study was to investigate the ...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
ConclusionAF inhibits Aβ1-42-induced neurotoxicity in animal and cellular models through AMPK/GSK3β-mediated pyroptosis suppression. Our results highlight AF as a clinical compound for the prevention and treatment of AD.
Source: Life Sciences - Category: Biology Source Type: research
In this study, the neuroprotective effects ofEcklonia maxima (KPM),Gracilaria gracilis (GCL),Ulva lactuca (ULT) andGelidium pristoides (MNP) in Zn –induced neurotoxicity in HT-22 cells was examined. Cells were treated with Zinc sulphate and/or aqueous - ethanol extracts and cell viability, apoptosis, acetylcholinesterase activity, including some antioxidant enzymes (catalase and superoxide dismutase activity) and glutathione (GSH) levels wer e determined. Malondialdehyde and nitric oxide levels produced in the Zn and/or seaweed extract treated cells were also determined. Prior treatment with the seaweed extracts impr...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
Publication date: Available online 14 November 2019Source: NeuroImageAuthor(s): Maria Julieta Mateos, Alfonso Gastelum Strozzi, Fernando A. Barrios, Ernesto Bribiesca, Sarael Alcauter, Jorge Marquez FloresAbstractA voxel-based method for measuring sulcal width was developed, validated and applied to a database. This method (EDT-based LM) employs the 3D Euclidean Distance Transform (EDT) of the pial surface and a Local Maxima labeling algorithm. A computational phantom was designed to test method performance; results revealed the method's inaccuracy δ, to range between 0.1 and 0.5 voxels, for a width that varied betwe...
Source: NeuroImage - Category: Neuroscience Source Type: research
Virtual reality is already used in medicine to train surgeons, fight phobias, and even help with early diagnosis of Alzheimer’s disease. Researchers at Drexel University have now taken the first steps to apply virtual reality in the field of ar...
Source: Medgadget - Category: Medical Devices Authors: Tags: Art Psychiatry Rehab Source Type: blogs
Conclusion: This study suggests that glutamine could protect against oxidative stress-induced injury in AD mice via the Wnt3a/β-catenin signaling pathway. PMID: 31119171 [PubMed - indexed for MEDLINE]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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