In vitro and in  vivo efficacy of Caenorhabditis elegans recombinant antimicrobial protein against Gram-negative bacteria.

This study reports how the C. elegans recombinant antibacterial factor (ABF-1) rapidly inhibited bacterial growth (Salmonella Typhi, Klebsiella pneumonia, Shigella sonnei and Vibrio alginolyticus). The ABF-1 exposure on S. Typhi, showed differential regulation in cell-cycle, DNA repair mechanism, membrane stability, and stress related proteins. The exogenous supply of ABF-1 protein has extended C. elegans survival by reducing the bacterial colony forming units on the nematode intestine. Together, these findings indicate the valuable and potential therapeutic applications of ABF-1 protein as antimicrobial agents against intracellular pathogens. PMID: 31617758 [PubMed - as supplied by publisher]
Source: Biofouling - Category: Molecular Biology Authors: Tags: Biofouling Source Type: research