Why context matters? Divisive normalization and Canonical microcircuits in psychiatric disorders

Publication date: Available online 16 October 2019Source: Neuroscience ResearchAuthor(s): Georg Northoff, Hajime MushiakeAbstractNeural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie context-dependence. Input summation and output normalization are mediated by input-output relationships in canonical microcircuits (CM). DN/CM are altered in psychiatric disorders like schizophrenia or depression whose various symptoms can be characterized by abnormal context-dependence.
Source: Neuroscience Research - Category: Neuroscience Source Type: research

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