Determination of whether supplemental oxygen therapy is beneficial during exercise training in patients with COPD: A systematic review and meta-analysis.

Determination of whether supplemental oxygen therapy is beneficial during exercise training in patients with COPD: A systematic review and meta-analysis. Exp Ther Med. 2019 Nov;18(5):4081-4089 Authors: Liu Y, Gong F Abstract Exercise training is an integral component of the pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to systematically search the published literature and analyze the evidence on the efficacy of supplemental oxygen in improving outcomes during exercise training in patients with COPD. The PubMed, Scopus, Cochrane Central Register of Controlled Trials (CENTRAL) and Google scholar databases were searched electronically for articles in the English language published up to May, 2019. In total, 7 trials were included in this systematic review and meta-analysis. There was considerable heterogeneity amongst the included studies. Meta-analysis indicated no significant difference in power (random: MD = -2.38; 95% CI, -5.79 to 1.03; P=0.86) and maximum energy expenditure (VO2 max) (random: MD = -0.01; 95% CI, -0.06 to 0.07; P=0.45) between the oxygen and control groups on maximal exercise testing. Qualitative analysis of the included studies revealed no benefits of supplemental oxygen in improving exercise capacity and dyspnea scores. Data on the quality of life assessed by the Chronic Respiratory Disease Questionnaire was pooled for 95 participants in the study group and 91...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research

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In this study, we analyzed the gene expression profiles of two datasets: one training dataset that includes 144 COPD patients and 194 ILD patients, and one test dataset that includes 75 COPD patients and 61 ILD patients. Advanced feature selection methods, mRMR (minimal Redundancy Maximal Relevance) and incremental feature selection (IFS), were applied to identify the 38-gene biomarker. An SVM (support vector machine) classifier was built based on the 38-gene biomarker. Its accuracy, sensitivity, and specificity on training dataset evaluated by leave one out cross-validation were 0.905, 0.896, and 0.912, respectively. And ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Condition:   COPD Intervention:   Other: Home PIFR monitoring with InCheck Dial Sponsor:   Michael (Brad) Drummond, MD, MHS Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Pulmonary Disease, Chronic Obstructive Intervention:   Sponsors:   AstraZeneca;   University of Oxford Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   COPD Intervention:   Other: Home PIFR monitoring with InCheck Dial Sponsor:   Michael (Brad) Drummond, MD, MHS Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: Participants with asthma or COPD had higher odds of tooth loss compared with those with neither asthma nor COPD. PRACTICAL IMPLICATIONS: People with asthma or COPD should maintain routine dental visits to reduce the risk of experiencing tooth loss. PMID: 31732091 [PubMed - as supplied by publisher]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
Abstract Transmigration of neutrophils through an epithelial layer, such as in the intestine or lung, is a necessary response to a perceived attack at the mucosal surface of that tissue. This process is dynamically regulated by a number of interactive events between the neutrophil and other cell types and allows for an effective and localized neutrophil response. However, in certain inflammatory diseases, including inflammatory bowel disease and chronic obstructive pulmonary disease (COPD), persistent neutrophil accumulation can contribute to disease pathology. Elucidating the mechanisms of this aberrant neutrophi...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
This paper introduces the use of low frequencies forced oscillation technique (FOT) in the presence of breathing signal. The hypothesis tested is to evaluate the sensitivity of FOT to various degrees of obstruction in COPD patients. The measurements were performed in the frequency range 0–2 Hz. The use of FOT to evaluate respiratory impedance has been broadly recognized and its complementary use next to standardized method as spirometry and body plethysmography has been well-documented. Typical use of FOT uses frequencies between 4–32 Hz and above. However, interesting information at frequencies below 4 Hz is r...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
PMID: 31739334 [PubMed - in process]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
The worst possible outcome when developing a clinical therapy is not an early failure. It is a late failure, in the final and most expensive phase III clinical trial, in which the therapy interacts with a sizable patient population, and after a great deal of time and funding have been devoted to the program. This result is far more likely for therapies based on mechanisms that have smaller rather than larger effect sizes, and where that smaller effect size varies from individual to individual for reasons that are not well understood - something that describes all too much of the past few decades of efforts to treat age-rel...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Conditions:   COPD;   COPD, Early-Onset Interventions:   Diagnostic Test: oscillometry;   Diagnostic Test: multiple breath washout testing;   Diagnostic Test: spirometry;   Diagnostic Test: body plethysmography;   Diagnostic Test: fractional exhaled nitric oxide;   Diagnostic Test: transfer factor;   Diagnostic Test: health  status;   Diagnostic Test: computed tomography;   Diagnostic Test: induced sputum Sponsors:  ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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