An update on the I blood group system.

CONCLUSIONS: This update of the I blood group system (Cooling L. Polylactosamines, there's more than meets the "Ii": a review of the I system. Immunohematology 2010;26:133-55) continues to show the Ii antigens to be increasingly recognized as important posttranslational modifiers regulating cell adhesion, signaling, differentiation, and cancer. Ii antigens can modulate the immune response through the galectin lattice, as well as influence specific protein-protein interactions. Changes in GCNT2 and I expression accompany stem cell differentiation and are associated with tumor progression in melanoma and breast and colon cancer. Regulation of GCNT2 expression varies between cell types and differentiation. In red blood cell differentiation, GCNT2 is regulated by methylation, microRNAs, and mitogen-activated protein kinase signaling pathways. Methylation and microRNAs also play a prominent role in altering GCNT2 expression in several epithelial cancers. In congenital cataracts, GCNT2 mutations may account for 4-6 percent of all cases. GCNT2 may be particularly susceptible to gene deletion and rearrangements due to the density of Alu-repeat elements. PMID: 31621365 [PubMed - in process]
Source: Immunohematology - Category: Hematology Tags: Immunohematology Source Type: research

Related Links:

Contributor : Juan R Alvarez-DominguezSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensStem cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human stem cells differentiate into pancreatic islets in vitro by profiling DNA methylation, chromatin accessibility, and histone modification changes. We find that enhancer potential is reset upon lineage commitment, and show how pervasive epigenetic priming steers endocrine cell fates. Modeling islet differentiation and maturation regulatory circuits ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Homo sapiens Source Type: research
Publication date: Available online 15 November 2019Source: Carbohydrate PolymersAuthor(s): Urarika Luesakul, Songchan Puthong, Kanokwan Sansanaphongpricha, Nongnuj MuangsinAbstractA new positively charged nanoemulsion using quaternized chitosan (QCS) as a protective layer was developed to improve the stability and bioactivity of lipophilic active components. The anti-inflammatory Plai extract was chosen as both an active ingredient and an oil phase of the system. Compared with chitosan-coated nanoemulsion (NE2-CS) and uncoated nanoemulsion (NE1), the QCS coating could improve the stability of the Plai extract during 28 day...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 14 November 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Lina Zhu, Beibei Yang, Kun Qian, Liang Qiao, Yun Liu, Baohong LiuAbstractThe epithelial cell adhesion molecule (EpCAM) is a known biomarker of circulating tumor cells that plays an important role in tumor metastasis. The detection of EpCAM is vital for personalized diagnosis and therapy but is challenging because of its extremely low concentration in peripheral blood. In our work, an electrochemical aptasensor has been developed to quantitatively detect EpCAM at low concentrations. A gold electrode modified with an a...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01524H, PaperDongliang Song, Tianming Chen, Shuang Wang, Shilin Chen, Heping Li, Fan Yu, Jingyuan Zhang, Zhe Zhang As a highly invasive and the most prevalent malignancy, lung cancer remains the leading cause of cancer-associated mortality worldwide, especially in China. Microwave ablation (MWA) is a type of effective,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Contributor : Juan R Alvarez-DominguezSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensStem cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human stem cells differentiate into pancreatic islets in vitro by profiling DNA methylation, chromatin accessibility, and histone modification changes. We find that enhancer potential is reset upon lineage commitment, and show how pervasive epigenetic priming steers endocrine cell fates. Modeling islet differentiation and maturation regulat...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Contributor : Juan R Alvarez-DominguezSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensStem cell-derived tissues could transform disease research and therapy, yet most methods generate functionally immature products. We investigate how human stem cells differentiate into pancreatic islets in vitro by profiling DNA methylation, chromatin accessibility, and histone modification changes. We find that enhancer potential is reset upon lineage commitment, and show how pervasive epigenetic priming steers endocrine cell fates. Modeling islet differentiation and maturation regulat...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Ruben Carrasco ; Meng JiangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensColorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incurable due to molecular heterogeneity of tumor cells. The B-cell lymphoma 9 (BCL9) oncogene functions as a transcriptional co-activator of the Wnt/ β-catenin pathway, which plays critical roles in CRC pathogenesis. Here we have identified a β-catenin-independent function of BCL9 in a poor-prognosis subtype of CRC tumors characterized by expression of stromal and ne...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Angela C Court ; Alice Le-Gatt ; Patricia Luz-Crawford ; Eliseo Parra-Cris óstomo ; Victor Aliaga-Tobar ; Luis F Bátiz ; Rafael A Contreras ; María I Ortúzar ; Mónica Kurte ; Roberto Elizondo-Vega ; Vinicius Maracaja-Coutinho ; Karina Pino-Lagos ; Fernando E Figueroa ; Maroun KhourySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensMesenchymal stem cells (MSCs) have fueled ample translation for the treatment of immune mediated diseases. They exert immunoregulatory and tissue restoring effects. MSCmediated transfer of mitochondria (MitoT) ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Feixue Xu ; Xiaoqiang SiSeries Type : Expression profiling by arrayOrganism : Homo sapiensCADM1, an immunoglobulin superfamily member, frequently inactivated but function as a tumor suppressor in many solid tumors. However, how CADM1 expression in ovarian cancer cells and the mechanisms of its tumor suppressor function is not fully understood.We created ovarian cancer ES-2 cell lines in which CADM1 was stably up-regulated. Genes differentially expressed in CADM1-overexpressing ES-2 cells.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Contributors : Ewelina Szyma ńska ; Paulina Nowak ; Krzysztof Kolmus ; Magdalena Cybulska ; Krzysztof Goryca ; Edyta Derezińska-Wołek ; Anna Szumera-Ciećkiewicz ; Marta Brewińska-Olchowik ; Aleksandra Grochowska ; Katarzyna Piwocka ; Monika Prochorec-Sobieszek ; Michał Mikula ; Marta MiączyńskaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSomatic copy number alterations play a critical role in oncogenesis. Loss of chromosomal regions containing tumor suppressors can lead to collateral deletion of passenger genes. This can be exploited therapeutically if synthetic lethal part...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
More News: Cancer | Cancer & Oncology | Cataracts | Colon Cancer | Colorectal Cancer | Epithelial Cancer | Genetics | Hematology | Melanoma | Skin Cancer | Stem Cell Therapy | Stem Cells