Metformin-Decavanadate Treatment Ameliorates Hyperglycemia and Redox Balance of Liver and Muscle in a Rat Model of Alloxan-induced Diabetes

New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ02460C, PaperSamuel Trevi ño, Enrique Gonzalez-Vergara Diabetes mellitus is a pandemic expected to spread from 422 million patients in 2014 to 592 million patients in 2035. Type 1 diabetes mellitus (T1D) is characterized by both autoimmune... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research

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ConclusionThe findings from this study have established the need to improve current education and rehabilitation programmes for patients with CHF by addressing those factors significantly influencing their adherence to diet and medication.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
DiscussionHyperchloremic acidosis is associated with a non-anion gap, decrease in plasma bicarbonate and increase in plasma chloride. Rarely, as with this case, it may present with a high-anion gap. The use of bicarbonate therapy has shown improvement in cases of non-anion gap acidosis however there is very little data to support its role in high-anion gap hyperchloremic metabolic acidosis.
Source: African Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
This study aimed to investigate the mechanism of action of ginger extract and its compound, 6-shogaol, on pancreatic islets as well as on expressions of TRPV-1 and NMDAR2B in the spinal cord of streptozotocin (STZ)-induced mice model of PDN.Materials and methodsSixty-four 5–6 months old male-Balb/C mice were induced with 110 mg/kgBW STZ i.p., while eight mice were used as control group. Mice with blood glucose level ≥200 mg/d, that suffered hyperalgesia and allodynia were classified as PDN mice. Hot plate and von Frey filament tests were performed once a week until termination. At day 28 after considered as PDN,...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: AARP.org News - Category: American Health Source Type: news
Publication date: Available online 9 July 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Yi-Jing Sheen, Chih-Cheng Hsu, Yi-Der Jiang, Chien-Ning Huang, Jia-Sin Liu, Wayne Huey-Herng SheuBackground/PurposeDiabetes mellitus (DM) and DM-related complications place a high socioeconomic burden on individuals and society. Updating nationwide information periodically is thus pivotal to preventing DM and improving its management in Taiwan.MethodsWe used the National Health Insurance Research Database; disease diagnosis codes were assigned according to the International Classification of Diseases, 9th Revision, C...
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Abstract BACKGROUND/PURPOSE: Diabetes mellitus (DM) and DM-related complications place a high socioeconomic burden on individuals and society. Updating nationwide information periodically is thus pivotal to preventing DM and improving its management in Taiwan. METHODS: We used the National Health Insurance Research Database; disease diagnosis codes were assigned according to the International Classification of Diseases, 9th Revision, Clinical Modification. DM was defined as ≥3 outpatient visits or 1 hospitalization within a year. We excluded individuals with gestational DM, those with missing data, and tho...
Source: J Formos Med Assoc - Category: General Medicine Authors: Tags: J Formos Med Assoc Source Type: research
Conclusions: Bariatric surgery appears to be capable of partially reversing the obesity-related epigenome. The identification of potential epigenetic biomarkers predictive for the success of bariatric surgery may open new doors to personalized therapy for severe obesity. Introduction Obesity is currently a huge healthcare problem, worldwide, and is a risk factor for several diseases such as type 2 diabetes (T2D), cardiovascular disease and cancer (1). As the prevalence of obesity reaches pandemic proportions, this metabolic disease is estimated to become the biggest cause of mortality in the near future (2). In fact,...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Addressing physical inactivity has been part of the United Nations and World Health Organization (WHO) strategy since 2004, in order to reducing all-cause mortality [1]. However, slow decisive policy responses have attenuated all favorable effects of physical activity (PA) in non-communicable diseases. One of these pandemic diseases is diabetes mellitus (DM), with three main types; type 1 (T1), type 2 (T2) and gestational, among others (monogenic and secondary diabetes are less common), but all of them characterized by signs and symptoms of chronic hyperglycemia [2].
Source: Primary Care Diabetes - Category: Primary Care Authors: Source Type: research
There are 425 million people with diabetes mellitus in the world. By 2045, this figure will grow to over 600 million. Diabetes mellitus is classified among noncommunicable diseases. Evidence points to a key role of microbes in diabetes mellitus, both as infectious agents associated with the diabetic status and as possible causative factors of diabetes mellitus. This review takes into account the different forms of diabetes mellitus, the genetic determinants that predispose to type 1 and type 2 diabetes mellitus (especially those with possible immunologic impact), the immune dysfunctions that have been documented in diabete...
Source: Reviews in Medical Microbiology - Category: Microbiology Tags: VIROLOGY Source Type: research
Diabetes is the pandemic disease of the modern era, with 10% of these patients having type 1 diabetes mellitus. Despite the prevalence, morbidities and associated financial burden, treatment options have not changed since the introduction of injectable insulin. To date, over 40,000 pancreas transplants have been performed globally. It remains the only known method for restoring glycaemic control and thus curing type 1 diabetes mellitus
Source: The American Journal of Medicine - Category: Journals (General) Authors: Tags: Review Source Type: research
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