Sildenafil as a Rescue Agent Following Intestinal Ischemia and Reperfusion Injury

Acute mesenteric ischemia carries a significant morbidity. Measures to improve blood flow parameters to the intestine may ameliorate the disease. Sildenafil, a phosphodiesterase 5 inhibitor, increases cyclic guanosine monophosphate and has been shown to prevent the effects of ischemia when given before injury. However, its effects as a rescue agent have not been established. We therefore hypothesized that sildenafil, when given as a rescue agent for intestinal ischemia, would improve mesenteric perfusion, limit intestinal epithelial injury, and decrease intestinal leukocyte chemoattractants.

Source: Journal of Surgical Research - October 16, 2019 Category: Surgery Authors: Hannah M. Moore, Natalie A. Drucker, Brian D. Hosfield, W. Chris Shelley, Troy A. Markel Source Type: research