Hospital characteristics, rather than surgical volume, predict length of stay following colorectal cancer surgery.

CONCLUSION: No evidence was found that higher annual surgery volume was associated with lower LOS for patients undergoing colorectal cancer surgery. Our model showed strong evidence that differences in LOS efficiency between hospitals was driven by hospital contextual effects that were not predicted by provider volume. Further study is required to elucidate these inherent differences between hospitals. Implications for public health: Our model indicated improved efficiency would benefit the patient and medical system by lowering LOS and reducing expenditure by more than $3 million per year. PMID: 31617657 [PubMed - as supplied by publisher]
Source: Australian and New Zealand Journal of Public Health - Category: International Medicine & Public Health Authors: Tags: Aust N Z J Public Health Source Type: research

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Acute diverticulitis (AD) is a significant clinical and economic burden, with over 200,000 inpatient admissions and costs exceeding 2 billion dollars annually.1 Current guidelines recommend colonoscopy after AD resolution “in an effort to exclude misdiagnosis of colorectal cancer (CRC) in patients who have not undergone recent high-quality colonoscopy.”2 However, this is a conditional recommendation based on low-quality evidence. Some studies suggest that this recommendation may be too broad. Understanding the ri sk of CRC in persons with AD is a necessary starting point for identifying when colonoscopic evalua...
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Abstract Digital PCR enabled high-sensitivity and quantitative measurements of rare biological variants. A new digital droplet-enabled PCR technology was introduced in this paper, which partitioned genetic targets into a planar nanoliter droplet array by using a microfluidic impact printer (MIP) with a disposable microfluidic chip. The accuracy of this MIP-enabled PCR technology was verified by detecting a series of concentration gradients of GAPDH gene across spanning four orders of magnitude (from 0.464 copies/μL to 464 copies/μL). Furthermore, this technology was applied to detect the expressions of p53 g...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Publication date: Available online 20 February 2020Source: Seminars in Cancer BiologyAuthor(s): Wenhao Weng, Ajay GoelAbstractColorectal cancer (CRC) is one of most common malignancies worldwide and its incidence is still growing. In spite of recent advances in targeted therapies, their clinical efficacy has been limited, non-curative and unaffordable. A growing body of literature indicates that CRC is a multi-modal disease, where a variety of factors within the tumor microenvironment play a significant role in its pathogenesis. For instance, imbalance in gut microbial profiles and impaired intestinal barrier function cont...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
ConclusionsPreoperative sarcopenia is an independent prognostic factor of postoperative morbidity and shorter survival in CRC peritoneal metastasis patients treated with CRS –HIPEC. Our findings support the importance of preoperative screening for sarcopenia as part of preoperative risk assessment for better selection of CRS–HIPEC candidates or treatment modifications in CRC patients with peritoneal metastasis.
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
ConclusionMAD2L1, as a novel oncogenic gene, plays a role in regulating cancer cell growth and apoptosis and could be used as a new biomarker for diagnosis and therapy in CRC.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Conclusion Based on the RR, Conv R, and symptom palliation ability, mFOLFOXIRI+α was suggested to be a viable candidate for first-line treatment for patients with ARCC, especially those with a high tumor burden. PMID: 32074573 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
AbstractColorectal cancer (CRC) refers to a deadly carcinoma following potent invasiveness and metastasis in advanced stage. Unfortunately, existing anti ‐CRC medicine is insufficient for chemotherapy in addition to adverse effects. Consequently, the candidate natural ingredient for treating CRC needs to be further developed. Our previous experiments report that genistein exerts beneficial effects to inhibit CRC cells via an antiproliferative mecha nism. Based on the metastatic characteristics of staging CRC, anti‐invasive and antimetastatic pharmacological activities using genistein remain uninvestigated. The scientif...
Source: BioFactors - Category: Biochemistry Authors: Tags: Research Communication Source Type: research
Publication date: 25 April 2020Source: Journal of Industrial and Engineering Chemistry, Volume 84Author(s): Nea Young Chun, Se-Na Kim, Youn Seo Choi, Young Bin ChoyAbstractColorectal cancer is the second leading cause of cancer-related deaths worldwide. CRC is often treated with intravenous 5-fluorouracil (5FU). However, 5FU frequently shows low therapeutic efficacy and serious adverse events. Particulate drug carriers able to enhance intracellular delivery could be advantageous, since higher 5FU concentrations would be engulfed by cancer cells during a relatively short residence within the rectal space to improve local an...
Source: Journal of Industrial and Engineering Chemistry - Category: Chemistry Source Type: research
ConclusionPerforming a colon conduit in patients undergoing total pelvic exenteration for LARC or LRRC avoids the risks of ileo-ileal anastomotic leakage and may reduce the risk of a post-operative ileus. Besides, there are no other differences in outcome for ileal and colon conduits.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
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