Intraarticularly Injected Mesenchymal Stem Cells Stimulate Anti-Inflammatory Molecules and Inhibit Pain and Chondrolytic Enzymes in a Rat Model of Arthritis

Mesenchymal stem cells (MSCs) possess anti-inflammatory properties and tissue differentiation potential. We prepared a rat shoulder arthritis model by injecting monoiodoacetate (MIA) into the shoulder and investigated the intraarticular administration of MSCs from the aspects of the cartilage protective effect associated with the cell ’s anti-inflammatory activity and inhibition of the central sensitization of pain. When MIA was administered in this model, anti-calcitonin gene related peptide (CGRP) was expressed in the shoulder joint and C5 spinal dorsal horn.

Source: Journal of Shoulder and Elbow Surgery - October 18, 2019 Category: Orthopaedics Authors: Toru Ichiseki, Shusuke Ueda, Daisuke Souma, Miyako Shimasaki, Yoshimichi Ueda, Norio Kawahara Source Type: research