Lichen planus with multiple system involvement including the mouth, vagina, urethra, and scalp: a case report.

Lichen planus with multiple system involvement including the mouth, vagina, urethra, and scalp: a case report. Braz J Med Biol Res. 2019;52(10):e8823 Authors: Mi L, Zhang H, Zhang D, Zhang M Abstract This is a case report of lichen planus (LP) with multiple system involvement. A 35-year-old female patient was admitted in November 2014 with a 5-year history of painful/difficult sexual intercourse and loss of oral mucosa, and an 8-year history of focal hair loss. Earlier, the patient had been unable to adhere to corticosteroid therapy because of severe adverse side effects. In September 2014, labia minora mucosa defects and stricture of the urethral orifice (with dysuria), vaginal orifice, and vagina were identified. Biopsy was performed and a diagnosis of erosive LP was made. The patient was treated with an oral immunosuppressant (cyclosporine A) and urethral/vaginal dilatation. Urine flow rate and sex life were improved after 6 months and she discontinued medication. Four years later, the patient reported a good overall treatment efficacy. LP can involve multiple systems and should be considered in patients with dyspareunia. Immunosuppressive agents can achieve a satisfactory effect in patients with contraindication to corticosteroid. PMID: 31618369 [PubMed - in process]
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research

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A 62-year-old male with a long-standing history of discoid lupus erythematousus (DLE) and lichen planus (LP) overlap syndrome presented with new, dark brown lesions on his face and inside his mouth. He had also noticed worsening hair loss with scarring and pigment changes on the scalp. Physical exam revealed scattered atrophic, reticulated, hyperpigmented and hypopigmented alopecic patches with loss of follicular ostia and follicular plugging on the scalp. Exam of the face revealed irregular, hyperpigmented macules and atrophic plaques on the bilateral cheeks and chin.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Immunologic adverse reactions of β-blockers and the skin. Exp Ther Med. 2019 Aug;18(2):955-959 Authors: Tatu AL, Elisei AM, Chioncel V, Miulescu M, Nwabudike LC Abstract β-Blockers are a widely utilised class of medication. They have been in use for a variety of systemic disorders including hypertension, heart failure and intention tremors. Their use in dermatology has garnered growing interest with the discovery of their therapeutic effects in the treatment of haemangiomas, their potential positive effects in wound healing, Kaposi sarcoma, melanoma and pyogenic granuloma, and, more recently,...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
In this report, the authors report 2 cases of LP that presented primarily as hypopigmented macules in 2 African American men. The first patient presented with hypopigmented macules on face and scalp as well as trunk and extremities. The second patient presented with hypopigmented macules on scalp with associated alopecia. Histopathological examination from both patients showed features of LP. The authors propose a new variant of LP that presents acutely as hypopigmented lesions.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research
To the Editor: In the comprehensive review of lichen planus and lichenoid dermatoses by Tziotzios et  al,1 the authors suggest that frontal fibrosing alopecia (FFA) is a misnomer and a restrictive diagnosis. The central issue is whether FFA is only a distinct form of lichen planopilaris (LPP) or a more complex disorder.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: JAAD Online Source Type: research
We describe 2 such cases that highlight potential early warning signs. Recent findings In their 20s, one woman and one man developed EOMG (AChR antibody-positive), requiring extended transsternal removal of hyperplastic thymi at ages 35 and 27, respectively. Their myasthenia gravis was readily controlled for the next 10 and 7 years before deteriorating in both, with appearance of late clinical features and anticytokine autoantibodies suggesting underlying thymomas, namely respiratory infections, genital herpes, chronic candidiasis, and alopecia in the woman and erythroderma and lichen planus in the man, followed by Pseudo...
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Myasthenia, Paraneoplastic syndrome Review Source Type: research
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Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Clinical Image Source Type: research
Conclusions: IgG positivity helps significantly in differentiating LPP from DLE (P 0.004) and NSP from DLE (P 0.005). IgM positivity helps significantly in differentiating LPP from LP (P 0.04), LP from PPB (P 0.00) and NSP (P 0.00). C3 positivity helps significantly in differentiating PPB from DLE (P 0.02). PMID: 30706869 [PubMed - in process]
Source: Indian Journal of Pathology and Microbiology - Category: Pathology Authors: Tags: Indian J Pathol Microbiol Source Type: research
Abstract Type I interferons (IFNs) are an immunomodulatory class of cytokines that serve to protect against viral and bacterial infection. In addition, mounting evidence suggests IFNs, particularly type I but also IFNγ, are important to the pathogenesis of autoimmune and inflammatory skin diseases, such as cutaneous lupus erythematosus (CLE). Understanding the role of IFNs is relevant to anti-viral responses in the skin, skin biology, and therapeutics for these IFN-related conditions. Type I IFNs (α and β) are produced by recruited inflammatory cells and by the epidermis itself (IFNκ) and ha...
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
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Source: Dermatology - Category: Dermatology Source Type: research
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