Standardized acquisition and post-processing of dynamic susceptibility contrast perfusion in patients with brain tumors, cerebrovascular disease and dementia: comparability of post-processing software.

This study evaluates the results of perfusion analysis with two established software solutions in a large series of patients with different diseases when a highly standardized processing workflow is ensured. METHODS: Multicenter data of 260 patients (80 with brain tumors, 124 with cerebrovascular disease and 56 with dementia examined with the same MR protocol) were analyzed. Raw data sets were processed with two software suites: Olea sphere and NordicICE. Group differences were analyzed with paired t-tests and one-way ANOVA. RESULTS: Perfusion metrics were significantly different for all examined diseases in the unaffected brain for both software suites [ratio cortex/white matter left hemisphere: mean transit time (MTT) 0.991 vs 0.847, p
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research

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The objective of this review is to highlight the role of pericytes in cerebral microvessels as well as their relationships with stroke, dementia, and brain tumor disease. The possible pathogenic mechanisms between pericytes and these diseases will also be described. As a matter of fact, the role of pericytes in the brain-associated vascular disease may provide new ideas for clinical treatment. PMID: 31743876 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Authors: Carota A, Bogousslavsky J Abstract Hallucinations, delusions, and confabulations are common symptoms between neurology and psychiatry. The neurological diseases manifesting with such symptoms (dementia, epilepsy, Korsakoff's disease, brain tumors, Parkinson's disease, migraine, right hemisphere stroke and others) would be the key to understand their biological mechanisms, while the cognitive sciences, neuropharmacology and functional neuroimaging would be the tools of such researches. It is possible to understand the perceptive rules of the mind and the mechanisms of the human consciousness based on these ...
Source: Frontiers of Neurology and Neuroscience - Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research
Wei Li1†, Wei-Min Xiao1†, Yang-Kun Chen1*, Jian-Feng Qu1, Yong-Lin Liu1, Xue-Wen Fang2, Han-Yu Weng1 and Gen-Pei Luo11Department of Neurology, Dongguan People’s Hospital, Dongguan, China2Department of Radiology, Dongguan People’s Hospital, Dongguan, ChinaBackground: Anxiety is prevalent after a stroke. The pathophysiological mechanisms underlying the development of poststroke anxiety (PSA) remain unclear. The aim of this study was to investigate the clinical and neuroimaging risk factors for development of PSA and examine the effects of PSA on activities of daily living (ADL) and quality of life (...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In conclusion, in the Framingham Heart Study population, in the last 30 years, disease duration in persons with dementia has decreased. However, age-adjusted mortality risk has slightly decreased after 1977-1983. Consequences of such trends on dementia prevalence should be investigated. Recent Research on the Benefits of Exercise in Later Life A sizable body of work points to the ability of older individuals to continue to obtain benefits through regular physical activity, and particularly in the case ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Seizures are a common occurrence in end stage disease, occurring in a wide range of conditions, including dementia, stroke, AIDS, end stage renal disease, and both primary brain tumors and metastatic disease. Not only are uncontrolled seizures a significant source of distress to both patient and families, but they present a significant management challenge to the hospice team, who are often faced with controlling seizures in the face of advancing disease, increasing seizure risk factors, and declining ability of the patient to take oral medications.
Source: Journal of Pain and Symptom Management - Category: Palliative Care Authors: Source Type: research
Palliative medicine is a specialty that focuses on improving the quality of life for patients with serious or advanced medical conditions, and it is appropriate at any stage of disease, including at the time of diagnosis. Neurologic conditions tend to have high symptom burdens, variable disease courses, and poor prognoses that affect not only patients but also their families and caregivers. Patients with a variety of neurologic conditions such as Parkinson disease, dementia, amyotrophic lateral sclerosis, brain tumors, stroke, and acute neurologic illnesses have substantial unmet needs that can be addressed through a combi...
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Symposium on neurosciences Source Type: research
Conclusions: This study demonstrates that neurologic patients have a high proportion of AEs in hospital. The findings provide information on the quality and safety of care for people with neurologic conditions in hospital, which can help inform future quality improvement initiatives.
Source: Neurology - Category: Neurology Authors: Tags: All Health Services Research, Medical care, All Clinical Neurology, Patient safety ARTICLE Source Type: research
When my son Dan was diagnosed with severe obsessive-compulsive disorder, his psychiatrist informed me and my husband that Dan was “borderline psychotic.” In other words, our son was out of touch with reality. For most people, psychosis usually presents in one of two ways: Hallucinations – consist of seeing, hearing or feeling things that are not actually there. A common example is hearing voices. Delusions – consist of beliefs that are not likely to be true and that seem irrational or nonsensical to other people. A typical example involves believing that outside forces are controlling your thoughts...
Source: Psych Central - Category: Psychiatry Authors: Tags: Caregivers General Obsessive-Compulsive Disorder Psychology Delusions Hallucinations Psychosis psychotic behavior Source Type: news
We’ve all heard the saying, “age is just a number.” Nowhere is that more important than in the hospital setting. Over the years I’ve become more and more aware of ageism in healthcare – a bias against full treatment options for older patients. Assumptions about lower capabilities, cognitive status and sedentary lifestyle are all too common. There is a kind of “senior profiling” that occurs among hospital staff, and this regularly leads to inappropriate medical care. Take for example, the elderly woman who was leading an active life in retirement. She was the chairman...
Source: Better Health - Category: American Health Authors: Tags: Health Policy True Stories Ageism Bias healthcare Medicine Rehabilitation Senior Profiling Seniors Source Type: blogs
Conclusions: The prevalence of epi/sz in the elderly nursing home population is>7-fold higher compared to community-dwelling elderly and is 7 to 30 times higher among those with certain comorbid neurologic conditions. Demographics and clinical characteristics had weaker associations with epi/sz prevalence.
Source: Neurology - Category: Neurology Authors: Tags: All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia, Brain trauma, Prevalence studies, All Epilepsy/Seizures ARTICLE Source Type: research
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