20 Medical Technology Advances: Medicine In The Future – Part I

Mind-reading exoskeletons, digital tattoos, 3D printed drugs, RFID implants for recreational purposes: mindblowing innovations come to medicine and healthcare almost every single day. We shortlisted some of the greatest ideas and developments that could give us a glimpse into the future of medicine, but we found so many that we had trouble fitting them into one article. Here are the first ten spectacular medical innovations to watch for. 1) Mixed reality opens new ways for medical education Augmented, virtual, and mixed reality are all technologies opening new worlds for the human senses. While the difference between these technologies might seem arbitrary at first, it greatly determines how they could be used in healthcare. While AR lets users see the real world and projects digital information onto the existing environment, VR shuts out everything else completely and provides an entire simulation, mixed reality is able to interact with the world, while projecting information into it. Thus, AR can be used by surgeons for projecting potentially life-saving information into their eyesight during operations, VR can be used in psychiatry to treat phobias efficiently, and mixed reality is able to bring revolutionary novelties to medical education, or pre-operative surgical planning, among others. For example, the Microsoft HoloLens opens up radically new ways for medical education as it is able to project the human body in its full size in front of med students. Thus, th...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine 3d printing artificial food brain-computer interface cyborg digital tattoos drug development exoskeleton gamification google glass health insurance Healthcare Innovation List Medical education medical techn Source Type: blogs

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Authors: Sola A, Rodríguez S, Cardetti M, Dávila C Abstract Objective: To evaluate and report the clinical characteristics and outcomes of SARS-CoV-2 infection in pregnant women and newborns in Latin America. Methods: Descriptive study based on the prospective report of the units of the Ibero-American Society of Neonatology Network. Results: Of 86 pregnant women with COVID-19 confirmed by RT-PCR in seven countries (6 from Latin America, and Equatorial Guinea) 68% (59) were asymptomatic. Of 32% of symptomatic women, 89% (24) had mild symptoms and 3.5% (3) had severe respiratory symptoms. No wom...
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
In this study, we found only minor ethnic differences in persistent pain. Similar living conditions and cultural features may explain these findings. PMID: 32780007 [PubMed - in process]
Source: International Journal of Circumpolar Health - Category: International Medicine & Public Health Tags: Int J Circumpolar Health Source Type: research
Globoid cell leukodystrophy (GLD; Krabbe disease) is a progressive, incurable neurodegenerative disease caused by deficient activity of the hydrolytic enzyme galactosylceramidase (GALC). The ensuing cytotoxic accumulation of psychosine results in diffuse central and peripheral nervous system (CNS, PNS) demyelination. Presymptomatic hematopoietic stem cell transplantation (HSCT) is the only treatment for infantile-onset GLD; however, clinical outcomes of HSCT recipients often remain poor, and procedure-related morbidity is high. There are no effective therapies for symptomatic patients. Herein, we demonstrate in the natural...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Leber’s hereditary optic neuropathy (LHON) is a maternally inherited eye disease. X-linked nuclear modifiers were proposed to modify the phenotypic manifestation of LHON-associated mitochondrial DNA (mtDNA) mutations. By whole-exome sequencing, we identified the X-linked LHON modifier (c.157C>T, p.Arg53Trp) in PRICKLE3 encoding a mitochondrial protein linked to biogenesis of ATPase in 3 Chinese families. All affected individuals carried both ND4 11778G>A and p.Arg53Trp mutations, while subjects bearing only a single mutation exhibited normal vision. The cells carrying the p.Arg53Trp mutation exhibited defective...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
We report that deletion of Lmna in cardiomyocytes in mice leads to severe cardiac dysfunction, conduction defect, ventricular arrhythmias, fibrosis, apoptosis, and premature death within 4 weeks. The phenotype is similar to LMNA-associated cardiomyopathy in humans. RNA sequencing, performed before the onset of cardiac dysfunction, led to identification of 2338 differentially expressed genes (DEGs) in Lmna-deleted cardiomyocytes. DEGs predicted activation of bromodomain-containing protein 4 (BRD4), a regulator of chromatin-associated proteins and transcription factors, which was confirmed by complementary approaches, includ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Connexin-43 (Cx43) gap junctions provide intercellular coupling, which ensures rapid action potential propagation and synchronized heart contraction. Alterations in Cx43 localization and reductions in gap junction coupling occur in failing hearts, contributing to ventricular arrhythmias and sudden cardiac death. Recent reports have found that an internally translated Cx43 isoform, GJA1-20k, is an auxiliary subunit for the trafficking of Cx43 in heterologous expression systems. Here, we have created a mouse model by using CRISPR technology to mutate a single internal translation initiation site in Cx43 (M213L mutation), whi...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Although the control of bone-resorbing osteoclasts through osteocyte-derived RANKL is well defined, little is known about the regulation of osteoclasts by osteocyte death. Indeed, several skeletal diseases, such as bone fracture, osteonecrosis, and inflammation are characterized by excessive osteocyte death. Herein we show that osteoclasts sense damage-associated molecular patterns (DAMPs) released by necrotic osteocytes via macrophage-inducible C-type lectin (Mincle), which induced their differentiation and triggered bone loss. Osteoclasts showed robust Mincle expression upon exposure to necrotic osteocytes in vitro and i...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: Available online 9 August 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): María Julia Ferronato, Serrano Mercedes Nadal, Enrique Javier Arenas Lahuerta, Cristina Bernadó Morales, Giuliana Paolillo, Aliguer Alex Martinez-Sabadell, Marilina Mascaró, Cristian Vitale, Yagamare Fall, Joaquín Arribas, María Marta Facchinetti, Alejandro Carlos Curino
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 9 August 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Yuan Hua Chen, Zhi Bing Liu, Li Ma, Zhi Cheng Zhang, Lin Fu, Zhen Yu, Wei Chen, Ya Ping Song, Peng Wang, Hua Wang, De Xiang Xu
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 12 August 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): Vinícius Dokkedal-Silva, José Carlos Fernandes Galduróz, Sergio Tufik, Monica L. Andersen
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
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