REIIBP is a histone methyltransferase overexpressed in T(4;14) multiple myeloma with oncogenic potential

Multiple Myeloma (MM), characterized by the uncontrolled proliferation of malignant plasma cells in the bone marrow, occurs mainly in the elderly population. Recurrent chromosomal translocations are central to the pathogenesis of MM, with t(4;14) being the second-most common and associated with poor prognosis. The histone methyltransferase (HMTase) MMSET is overexpressed in MM as a result of the t(4;14) translocation. MMSET is capable of producing 3 major isoforms, MMSET II, REIIBP and MMSET I. MMSET II encodes the full-length protein of 1365 amino acids and possesses HMTase activity for H3K36 and H4K20.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 30, 2019 Category: Hematology Authors: Jing Yuan Chooi, Muhammad Irfan Bin Azaman, Zhengwei Wu, Sabrina Hui Min Toh, Zhigang Xie, Jianhe Peng, Wee Joo Chng Source Type: research