IgH translocations with undefined partners are associated with superior outcome in multiple myeloma patients

Multiple myeloma (MM) is a genetically complex and heterogeneous disease with multiple genomic events associated with tumor development and progression.Chromosomal translocations into the immunoglobulin heavy-chain (IgH) locus on 14q32 are the main primary events, occurring in about 50% of total MM cases.Currently, there are five main chromosomal translocation partners involving with immunoglobulin heavy-chain (IgH), including t(4;14), t(6;14), t(11;14), t(14;16) and t(14;20). However, IgH translocation with undefined partner genes can still be found in 15% of all newly-diagnosed MM (NDMM) patient, and little is known about their survival.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 30, 2019 Category: Hematology Authors: xuehan Mao, Yan Xu, yuting Yan, Liu Jiahui, Fan huishou, Sui Weiwei, lizengjun zengjun, shuhui deng, Shuhua Yi, Tingyu Wang, Qi Wang, Hui-Min Liu, Wen-Jie Xiong, Chenxing Du, mu hao, Lugui Qiu, gang An Source Type: research