A New ‘Vicious Cycle’: Bidirectional Interactions Between Myeloma Cells and Adipocytes

The bone marrow (BM) microenvironment allows for migration, growth, proliferation, and drug-resistant clonal evolution of multiple myeloma (MM) cells. BM adipocytes (BMAs) expand with aging and obesity, two key MM risk factors. BMAs are important contributors to systemic adipokine levels, bone health and hematopoiesis, and have also recently been implicated in acute myeloid leukemia. We investigated the interactions between MM cells and BMAs and found that adipocyte gene expression and cytokine secretion profiles are altered, creating a "MM-associated ” adipocyte (MM-adipocyte) phenotype that is supportive of MM cell survival.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 30, 2019 Category: Hematology Authors: Heather Fairfield Campbell, Mariah Farrell, Carolyne Falank, Amel Dudakovic, Samantha Costa, Victoria DeMambro, Jessica Pettitt, Andre J. van Wijnen, Michelle McDonald, Michaela Reagan Source Type: research