Downregulation of methylation and demethylation enzymes in unsorted cell population of multiple myeloma patients

DNA methyltransferases (DNMTs) including DNMT1, DNMT3A and DNMT3B, catalyze the transfer of methyl groups to cytosine position 5, and play an important role in epigenetic regulation, which could be involved in pathogenesis of multiple myeloma (MM). Active DNA demethylation occurs during 5-methylcytosine through TET (Ten Eleven Translocation) enzyme-mediated oxidation removal, and this process is necessary for the epigenetic reprograming of genes and is directly involved in tumor progression.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 30, 2019 Category: Hematology Authors: Katerina Smesny Trtkova, Veronika Frybortova, Petra Luzna, Denisa Hrckova Drozdkova, Petra Krhovska, Jitka Proskova, Karin Joehrer, Jiri Minarik Source Type: research