Osteolytic disease in IL-6 and Myc dependent mouse model of human myeloma

Myeloma bone disease (MBD) is an important unmet medical need characterized by focal and generalized bone loss causing severe pain, pathological fractures, instability of the vertebral column, and medullary cord / spinal nerve root compression. MBD is a disease-defining feature of multiple myeloma, the second most common blood cancer in the United States. MBD is poorly recapitulated in genetically engineered mouse models (GEMMs) of human myeloma developed in the past. Objective: To address this shortcoming, we determined onset, incidence and severity of osteolytic disease in a new GEMM of human myeloma developed in our laboratory.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research