In Cardiac AL Amyloid a Higher BMI is Associated with a Lower Rate of Cardiac Response

Light-chain amyloidosis (AL) is a clonal plasma cell disorder in which Ig light chains cause organ-specific disease due to toxic misfolded light-chain aggregates and extracellular deposition of amyloid fibrils derived from light chain proteins. Approximately half of AL amyloid patients present with cardiac involvement and survival is largely driven by the extent of heart failure. In the general heart failure population, overweight and mild/moderate obesity is associated with lower mortality, termed the obesity survival paradox.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 30, 2019 Category: Hematology Authors: So Yeon Kim, Raymond L. Comenzo, Amanda Vest, Cindy Varga Source Type: research