Dysregulation of the B-Cell Receptor Pathway Through Alternative Splicing in Waldenstrom ’s Macroglobulinemia

B-cell receptor (BCR) and toll-like receptor (TLR) pathway activation are key drivers of pro-survival signaling in many B-cell and plasma cell malignancies. Both pathways are notable for their activation of common cascades that include BTK, PI3K/AKT, MAPK1 and MAPK3 (ERK1 and ERK2 at the protein level) signaling, as well as the activation and nuclear translocation of nuclear factor kappa-B (NFkB). In Waldenstrom's Macroglobulinemia (WM), the TLR pathway is driven by activating mutations in MYD88 that are found in 95-97% of patients.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Source Type: research