Dysregulation of the B-Cell Receptor Pathway Through Alternative Splicing in Waldenstrom ’s Macroglobulinemia
B-cell receptor (BCR) and toll-like receptor (TLR) pathway activation are key drivers of pro-survival signaling in many B-cell and plasma cell malignancies. Both pathways are notable for their activation of common cascades that include BTK, PI3K/AKT, MAPK1 and MAPK3 (ERK1 and ERK2 at the protein level) signaling, as well as the activation and nuclear translocation of nuclear factor kappa-B (NFkB). In Waldenstrom's Macroglobulinemia (WM), the TLR pathway is driven by activating mutations in MYD88 that are found in 95-97% of patients.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Nickolas Tsakmaklis, Amanda Kofides, Maria Demos, Lian Xu, Xia Liu, Guang Yang, Manit Munshi, Jiaji Chen, Maria Luisa Guerrera, Cristina Jimenez, Gloria Chan, Jorge Castillo, Steven Treon, Zachary Hunter Source Type: research
More News: Cancer & Oncology | Hematology | Leukemia | Lymphoma | Macroglobulinemia | Myeloma | Translocation | Waldenstrom's Macroglobulinemia