P3. Abstract Title: A Point-of-Care Assay for Measuring Thrombin Activity in Finger-Prick Whole Blood

At sites of vessel injury, thrombin acts as the central mediator of coagulation through catalyzing fibrin clot formation and platelet activation. Thus, numerous commercially available small molecule chromogenic and fluorogenic substrates have been developed to evaluate thrombin activity. These substrates are limited in that they detect both active thrombin and thrombin bound to its inhibitor α2-macroglobulin, have limited specificity for thrombin and can only be used in plasma samples because of signal quenching.

Source: Thrombosis Research - September 30, 2019 Category: Hematology Authors: Y. Dai, P. Gross Source Type: research