OC4. Abstract Title: Thrombus Stability Explains the Factor V Leiden Paradox: A Mouse Model

Factor V Leiden (FVL) is an inherited autosomal dominant condition that is identified in 20%-50% of patients with venous thromboembolic diseases and 5-8% of the population in Canada. People with FVL are often called hypercoagulable, and have a five-fold increase in the risk of venous thrombosis. There is a low prevalence of FVL among patients with fatal pulmonary embolism (PE) and a higher incidence of deep vein thrombosis (DVT) than PE in patients with FVL. This has been referred to as the FVL paradox in thrombosis.

Source: Thrombosis Research - September 30, 2019 Category: Hematology Authors: S. Shaya, P. Gross, R. Westrick Source Type: research