Role of Biological Agents in Treatment of Rheumatoid Arthritis

Publication date: Available online 17 October 2019Source: Pharmacological ResearchAuthor(s): Shing T. Law, Peter C. TaylorAbstractAdvances in understanding of the pathophysiology of rheumatoid arthritis with concurrent advances in protein engineering led to the development of biological disease-modifying antirheumatic drugs which have dramatically revolutionized the treatment of this condition. This review article focuses on the role of biological agents currently employed in the treatment of rheumatoid arthritis, as well as novel biological agents in development.Graphical abstract
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research

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CONCLUSIONCollectively, it is possible that combination therapy can be applied as a beneficial strategy to control RA.Graphical abstract
Source: Life Sciences - Category: Biology Source Type: research
ConclusionsSuvarna Bhasma contained spherical gold nanoparticles. It was nontoxic in rat model at the does tested. Suvarna Bhasma has anxiolytic effects in zebrafish behavioural model.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe updated recommendations of the Mexican College of Rheumatology on the pharmacological treatment of rheumatoid arthritis incorporate the best available information to be used in the Mexican health care system.ResumenLos avances terapéuticos en la artritis reumatoide obligan a revisión periódica de las guías de tratamiento.ObjetivoActualizar las guías del Colegio Mexicano de Reumatología del tratamiento farmacológico de la artritis reumatoide.MétodoParticiparon reumatólogos certificados de diferentes instituciones de salud y regiones del paí...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
This study evaluated spebrutinib pharmacology and mechanism of action over a 4-week treatment period in patients with active rheumatoid arthritis (RA).MethodsPrimary human B cells, T cells, natural killer cells, macrophages, dendritic cells, basophils, and osteoclasts were treated with spebrutinib in vitro. Clinical pharmacodynamics were studied in 47 patients with active RA on background methotrexate therapy randomized to oral spebrutinib 375  mg/day or placebo.ResultsIn vitro, spebrutinib inhibited B-cell proliferation more potently than T-cell proliferation and reduced both lymphoid and myeloid cytokine production ...
Source: Rheumatology and Therapy - Category: Rheumatology Source Type: research
Autoimmune rheumatic diseases, such as Sjögren syndrome (SS) and rheumatoid arthritis (RA), are characterized by chronic inflammation and autoimmunity, which cause joint tissue damage and destruction by triggering reduced mobility and debilitation in patients with these diseases. Initiation and maintenance of chronic inflammatory stages account for several mechanisms that involve immune cells as key players and the interaction of the immune cells with other tissues. Indeed, the overlapping of certain clinical and serologic manifestations between SS and RA may indicate that numerous immunologic-related mechanisms are i...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
AbstractIntroductionRheumatoid arthritis (RA) is a chronic systemic auto-immune disease associated with a prothrombotic state. Tocilizumab, an interleukin-6 receptor inhibitor, is highly effective in controlling disease activity and thrombotic risk. Factor XIII (FXIII), involved in thrombotic complications, has been reported to be reduced in RA patients during maintenance treatment with tocilizumab, but no data are available before and after the drug administration. Thus, we investigated the effects of tocilizumab on FXIII, thrombin generation and inflammation in patients with RA na ïve for the drug.MethodsWe studied ...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Due to a single error in the annual cost of sarilumab the following needs to be corrected in the article.
Source: PharmacoEconomics - Category: Health Management Source Type: research
ConclusionsCrowned dens syndrome should be considered, and craniocervical junction imaged in the context of acute cervical or occipital pain with stiffness and elevated inflammation markers not only in patients previously diagnosed with calcium pyrophosphate dehydrate arthropathy but also in diverse clinical settings.Key Points•This report highlights that crowned dens syndrome should be considered in various clinical setting besides calcium pyrophosphate dehydrate (CPPD) arthropathy.• Vigilance to this syndrome allows rapid treatment and may spare the patient unnecessary invasive procedures (i.e., temporal artery...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
ConclusionsNeither MRI nor US showed satisfactory diagnostic test accuracy in detecting bone erosion. However, the 1.5-T Signa MRI system, General Electric ©, and different models of LOGIQ US units and General Electric© showed similarly good performance in detecting bone erosion in RA patients, while the 2nd metacarpophalangeal joint is the best recommended scanning position during US.Key Points:• In this study, we evaluated the diagnostic accuracy of US and MRI for bone erosion in RA patients, neither MRI nor US showed perfect diagnostic test accuracy.• 1.5-T Signa system and the LOGIQ units both from ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
This study focused on the potential therapeutic effect of wogonin on complete Freund's adjuvant (CFA) induced RA in rats and the underlying mechanisms. Arthritis was experimentally caused in rats by subcutaneously injecting 0.1 mL of CFA into the subplantar area of the left hind paw under moderate anesthesia on day zero. The regular oral doses of indomethacin/wogonin began on day zero and proceeded after injection to day 35. Wogonin reduced arthritic score considerably, enhanced body weight, and reduced paw thickness. Wogonin also boosted red blood cell considerably along with hemoglobin and reduced white blood cell count ...
Source: BioFactors - Category: Biochemistry Authors: Tags: Research Communication Source Type: research
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