Dissecting the m6A methylation affection on afatinib resistance in non-small cell lung cancer

The Pharmacogenomics Journal, Published online: 17 October 2019; doi:10.1038/s41397-019-0110-4Dissecting the m6A methylation affection on afatinib resistance in non-small cell lung cancer
Source: The Pharmacogenomics Journal - Category: Drugs & Pharmacology Authors: Source Type: research

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Authors: Nardone V, Tini P, Pastina P, Botta C, Reginelli A, Carbone SF, Giannicola R, Calabrese G, Tebala C, Guida C, Giudice A, Barbieri V, Tassone P, Tagliaferri P, Cappabianca S, Capasso R, Luce A, Caraglia M, Mazzei MA, Pirtoli L, Correale P Abstract Immune checkpoint blockade is an emerging anticancer strategy, and Nivolumab is a human mAb to PD-1 that is used in the treatment of a number of different malignancies, including non-small cell lung cancer (NSCLC), kidney cancer, urothelial carcinoma and melanoma. Although the use of Nivolumab prolongs survival in a number of patients, this treatment is hampered b...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Guo S, Li M, Li J, Lv Y Abstract Effect of targeted regulation of mothers against decapentaplegic homolog 3 (Smad3) by microRNA-15a (miR-15a) on the proliferation, invasion and metastasis of non-small cell lung cancer (NSCLC) cells and its related mechanisms were investigated. Fifty pairs of NSCLC and para-cancerous tissues were collected to identify the expression level of miR-15a in NSCLC, para-cancerous tissue, and cell lines A549, H1299, H1975 and BEAS-2B by real-time fluorescence quantitative PCR (RT-PCR); A549 cells were transfected with miR-15a mimic; the MTT assay was performed to detect the role o...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Lou M, Gao Z, Zhu T, Mao X, Wang Y, Yuan K, Tong J Abstract As a member of the tripartite motif family, tripartite motif-containing protein 59 (TRIM59) serves as an E3 ubiquitin ligase in various cellular processes, including intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy and carcinogenesis. The present study aimed to investigate the expression and prognostic value of TRIM59 in patients with non-small cell lung cancer (NSCLC). Expression of TRIM59 in patients with NSCLC was measured by immunohistochemistry in tissue microarrays. Datasets from The Cancer...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, our study provides evidence of the prognostic function of CENPF in NSCLC. PMID: 31966068 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Condition:   Non-Small Cell Lung Cancer Intervention:   Diagnostic Test: Perioperative ctDNA Dynamic Monitoring Sponsors:   Sun Yat-sen University;   Hangzhou Repugene Technology Co., Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Advanced Cancer;   Advanced Solid Tumor;   Lung Cancer, Nonsmall Cell Intervention:   Drug: SAF-189 Sponsor:   Shanghai Fosun Pharmaceutical Development Co, Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(Josep Carreras Leukaemia Research Institute) Researchers from IJC reveal that non-smoking patients with lung cancer that have an alteration in RB1 and are treated with EGFR inhibitors, acquire resistance to treatment through the mechanism of histopathological transformation, either to non-small cell lung cancer (SCLC) or SLCL combined with a transformation to squamous cell lung cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Publication date: Available online 22 January 2020Source: Life SciencesAuthor(s): Ravi Kumar, Mansi Awasthi, Anamika Sharma, Yogendra Padwad, Rohit SharmaAbstractAimEmerging studies have shown that application of low concentration of bioactive phytomolecules can confer anti-proliferative effects on tumour cells by inducing senescence pathways. The alkaloid berberine is recognized for its anti-cancer attributes but its potential to induce senescence in tumour cells is least understood.Materials and methodsThe present work assessed the mechanisms pertaining to dose-dependent anti-proliferative effects of berberine in the per...
Source: Life Sciences - Category: Biology Source Type: research
Conclusion: PCI reduces the incidence of BM except for patients with poor performance status. However, PCI fails to prolong OS significantly for NSCLC. An individual patient data meta-analysis may identify patients that could achieve OS prolongation with PCI.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
AbstractObjectiveTo evaluate the effect of Chinese herbal medicine formula, modified Liujunzi Decoction ( 六君子汤, MLJZT), for anorexia, utilized as adjunct therapy during chemotherapy treatment for patients with advanced non-small cell lung cancer (NSCLC).MethodsThe study adopted a propensity score-matched design based on a prospective database. From February 2016 to September 2017, patients with advanced NSCLC that received both cisplatin-based chemotherapy and MLJZT (IM group) were 1:1 propensity score-matched to patients that received the cisplatin-based chemotherapy alone (control group). Changes in anorexia and ...
Source: Chinese Journal of Integrative Medicine - Category: Internal Medicine Source Type: research
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