Long-Term Outcomes of Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression

American Journal of Psychiatry, Ahead of Print.
Source: American Journal of Psychiatry - Category: Psychiatry Authors: Source Type: research

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ConclusionThe here proposed corticopetal approach of a hierarchical description of 8 subcortical PPs with subcortical and cortical convergences represents a new systematics of networks found in all different evolutionary and distinct parts of the human brain.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionsIn this cohort, amantadine was used in 10% of patients. Its use increased during follow-up, despite the fact that one-third of patients who received amantadine at baseline stopped taking it. Amantadine prescription was mainly correlated with the presence of dyskinesia.
Source: Drugs and Aging - Category: Geriatrics Source Type: research
Publication date: Available online 7 January 2020Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Petya Vicheva, Matthew Butler, Paul ShotboltAbstractDeep brain stimulation (DBS) is considered a promising intervention for treatment-resistant obsessive-compulsive disorder (trOCD). We conducted a systematic search to investigate the efficacy and safety of DBS for OCD. Primary outcomes included the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), adverse events (AE), and quality of life. We assessed affective state, global functioning, cognition, and tolerability as secondary outcomes. Eight studies comprising 80 pati...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Deep brain stimulation (DBS) may lead to improvements in patients with treatment-resistant obsessive-compulsive disorder (OCD), reports astudy published today in AJP in Advance.In the open study of 70 OCD patients who received DBS of a region called the ventral anterior limb of the internal capsule (vALIC), Damiaan Denys, M.D., Ph.D., of the University of Amsterdam and colleagues found that during the first year following the procedure, patients on average experienced significant improvements in symptoms of OCD, anxiety, and depression. The findings support the results of a DBS trial involving 16 OCD patients reported in 2...
Source: Psychiatr News - Category: Psychiatry Tags: ajp in advance anxiety Damiann Denys deep brain stimulation depression HAM-A HAM-D obsessive-compulsive disorder Y-BOCS Source Type: research
Abstract OBJECTIVE: Deep brain stimulation (DBS) is an effective treatment option for patients with refractory obsessive-compulsive disorder (OCD). However, clinical experience with DBS for OCD remains limited. The authors examined the tolerability and effectiveness of DBS in an open study of patients with refractory OCD. METHODS: Seventy consecutive patients, including 16 patients from a previous trial, received bilateral DBS of the ventral anterior limb of the internal capsule (vALIC) between April 2005 and October 2017 and were followed for 12 months. Primary effectiveness was assessed by the change in sco...
Source: The American Journal of Psychiatry - Category: Psychiatry Authors: Tags: Am J Psychiatry Source Type: research
ConclusionsIn conclusion, the Czech translation of FoG-Q is valid. With respect to gait and balance, FoG-Q does, to a certain extent, reflect the native state of the disease in patients treated with high frequency STN DBS.
Source: Neurological Sciences - Category: Neurology Source Type: research
Publication date: January 2020Source: The Lancet Psychiatry, Volume 7, Issue 1Author(s): Rajamannar Ramasubbu, Darren L Clark, Sandra Golding, Keith S Dobson, Aaron Mackie, Angela Haffenden, Zelma HT KissSummaryBackgroundStimulation adjustment is required to optimise outcomes of deep brain stimulation (DBS) for treatment-resistant depression, but controlled data for ideal stimulation parameters are poor or insufficient. We aimed to establish the efficacy and safety of short pulse width (SPW) and long pulse width (LPW) subcallosal cingulate DBS in depression.MethodsWe did a double-blind, randomised, crossover trial in an ac...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Publication date: January 2020Source: The Lancet Psychiatry, Volume 7, Issue 1Author(s): Isidoor O Bergfeld
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder featuring repetitive intrusive thoughts and behaviors associated with a significant handicap. Of patients, 20% are refractory to medication and cognitive behavioral therapy. Refractory OCD is associated with suicidal behavior and significant degradation of social and professional functioning, with high health costs. Deep brain stimulation (DBS) has been proposed as a reversible and controllable method to treat refractory patients, with meta-analyses showing 60% response rate following DBS, whatever the target: anterior limb of the internal capsule (ALIC), v...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Authors: Harati S, Crowell A, Mayberg H, Nemati S Abstract Mental health patients often undergo a variety of treatments before finding an effective one. Improved prediction of treatment response can shorten the duration of trials. A key challenge of applying predictive modeling to this problem is that often the effectiveness of a treatment regimen remains unknown for several weeks, and therefore immediate feedback signals may not be available for supervised learning. Here we propose a Machine Learning approach to extracting audio-visual features from weekly video interview recordings for predicting the likely outco...
Source: Pacific Symposium on Biocomputing - Category: Bioinformatics Tags: Pac Symp Biocomput Source Type: research
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