Early Detection and Preventive Intervention in Schizophrenia: From Fantasy to Reality

American Journal of Psychiatry,Volume 176, Issue 10, Page 794-810, October 01, 2019.
Source: American Journal of Psychiatry - Category: Psychiatry Authors: Source Type: research

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Publication date: Available online 16 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Minjing Shao, Chuanjun Zhuo, Xiangyang Gao, Ce Chen, Yong Xu, Hongjun Tian, Gongying Li, Deguo Jiang, Wenqiang WangAbstractImportanceIt has been suggested that patients with schizophrenia have higher than expected mortality following acute coronary events. However, the in-hospital revascularization rate in patients with schizophrenia and acute myocardial infarction (AMI) compared to mentally healthy patients remains unknown.ObjectiveTo evaluate the revascularization rate in schizophrenic patien...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
This study aimed to investigate the platelet oxidative stress in different stages of schizophrenia (i.e., chronic stable and acute relapse) in order to clarify the clinical implications of oxidative stress and the treatment effects. We recruited 43 chronic stable patients with schizophrenia and 48 non-psychiatric controls. Platelets were collected for measuring the level of nitric oxide (NO), lipid peroxidation (LPO), and glutathione (GSH) and the activity of GSH peroxidase (GPx) and superoxide dismutase (SOD). The levels and activity were compared between patients and controls and were examined for their relationship with...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
In this study, patients didn’t need a smartphone[PM1] . It could be simple and low tech on the patient end, and high tech on the backend.”Researchers hope that artificial intelligence that can analyze data collected from apps such as My Coach Connect will enable more proactive and personalized care for individuals. The application, for example, may help improve treatment by intervening early when someone is experiencing more symptoms.“Artificial intelligence allowed us to illuminate the various clinically meaningful dimensions of language use and vocal patterns of the patients over time and pers...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
It's widely assumed antipsychotics increase the risk of CVD and early death in patients with schizophrenia. However, new findings suggest the opposite may be true and that these agents may in fact be protective.Medscape Medical News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Psychiatry News Source Type: news
In this study, polyinosinic:polycytidylic acid was administered to rats intravenously at a dose of 10 mg/kg on embryonic day 9.5 to produce MIA. The effect of MIA on behavior and ERK phosphorylation within the prefrontal cortex and the hippocampus of adolescent and adult offspring were explored. We also examined neurofilaments, a marker of neurogenesis, which have been reported to be modulated by ERK signaling. The results demonstrate an age- and region-specific profile of ERK expression and phosphorylation and suggest possible relationships among ERK, neurofilament expression, and cognitive performance in schizophrenia.
Source: Physiology and Behavior - Category: Physiology Source Type: research
INTRODUCTION: Schizophrenia, bipolar disorder and schizoaffective disorders are severe mental illnesses (SMI) associated with high levels of co-morbid psychopathology and premature mortality. Reducing delays in accessing services and providing early interv...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
One of the most challenging tasks of the post-genome-wide association studies (GWAS) research era is the identification of functional variants among those associated with a trait for an observed GWAS signal. Several methods have been developed to evaluate the potential functional implications of genetic variants. Each of these tools has its own scoring system, which forces users to become acquainted with each approach to interpret their results. From an awareness of the amount of work needed to analyze and integrate results for a single locus, we proposed a flexible and versatile approach designed to help the prioritizatio...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Neuropsychopharmacology, Published online: 17 January 2020; doi:10.1038/s41386-020-0614-2Downregulated AKT-mTOR signaling pathway proteins in dorsolateral prefrontal cortex in Schizophrenia
Source: Neuropsychopharmacology - Category: Neurology Authors: Source Type: research
It's widely assumed antipsychotics increase the risk of CVD and early death in patients with schizophrenia. However, new findings suggest the opposite may be true and that these agents may in fact be protective.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news
It's widely assumed antipsychotics increase the risk of CVD and early death in patients with schizophrenia. However, new findings suggest the opposite may be true and that these agents may in fact be protective.Medscape Medical News
Source: Medscape Pharmacist Headlines - Category: Drugs & Pharmacology Tags: Psychiatry News Source Type: news
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