Sex difference in IL-6 modulation of cognition among Chinese individuals with major depressive disorder

Publication date: Available online 16 October 2019Source: Journal of Clinical NeuroscienceAuthor(s): Na Qu, Shu-Fang Zhang, Bin Xia, Jia-Zhao Xie, Xiao-Ming Wang, Jun Liu, Jie Xiong, Na Ren, Yan Wang, Qing Tian, Yi LiAbstractCognitive dysfunction and pro-inflammatory effect has been associated with major depressive disorder (MDD), but sex differences have seldom been studied. The study was to determine the sex difference of cognitive dysfunction and pro-inflammatory biomarkers among patients with MDD in Chinese Han population. 104 MDD patients (male n = 37, female n = 67) were included in the study. Their sociodemographic and clinical features, including age, body mass index (BMI), education, smoking, alcohol use, illness characteristics and medicine use were recorded. Montreal Cognitive Assessment (MoCA) was used to assess cognition. And we detected pro-inflammatory biomarkers Interleakin-1β (IL-1β), Interleakin-6 (IL-6) and C-reaction protein (CRP) levels by enzyme linked immunosorbent assay. We found that male patients showed higher scores than female in MoCA, and performed better than female patients particularly in visuaspatial, naming, attention, orientation subscale. CRP and IL-1β levels showed no significant difference between male and female patients in MDD. However, Male’s IL-6 level was significantly declined than female, negative closed associated with cognition in MOCA score. These results suggested that the difference in IL-6 could reflect a cogniti...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research