Genetic and phenotypic characterization of recently discovered enterovirus D type 111

by Serge Alain Sadeuh-Mba, Marie-Line Joffret, Arthur Mazitchi, Marie-Claire Endegue-Zanga, Richard Njouom, Francis Delpeyroux, Ionela Gouandjika-Vasilache, Ma ël Bessaud Members of the speciesEnterovirus D (EV-D) remain poorly studied. The two first EV-D types (EV-D68 and EV-D70) have regularly caused outbreaks in humans since their discovery five decades ago but have been neglected until the recent occurrence of severe respiratory diseases due to EV-D68. The three other known EV-D types (EV-D94, EV-D111 and EV-D120) were discovered in the 2000s-2010s in Africa and have never been observed elsewhere. One strain of EV-D111 and all known EV-D120s were detected in stool samples of wild non-human primates, suggesting that these viruses could be zoonotic viruses. To date, EV-D111s are only known through partial genetic sequences of the few strains that have been identified so far. In an attempt to bring new pieces to the puzzle, we genetically characterized four EV-D111 strains (among the seven that have been reported until now). We observed that the EV-D111 strains from human samples and the unique simian EV-D111 strain were not phylogenetically distinct, thus suggesting a recent zoonotic transmission. We also discovered evidences of probable intertypic genetic recombination events between EV-D111s and EV-D94s. As recombination can only happen in co-infected cells, this suggests that EV-D94s and EV-D111s share common replication sites in the infected hosts. These sites cou...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research

Related Links:

China banned wildlife trade nationwide in markets, supermarkets, restaurants, and e-commerce platforms due to the coronavirus outbreak, the country's market watchdog, agricultural ministry, and forestry bureau said in a joint statement.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
The U.S. State Department said on Sunday it will evacuate personnel from its Wuhan consulate to the United States and will offer a limited number of seats to private U.S. citizens on a flight out of the epicenter of China's coronavirus outbreak.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
While China can mobilize a huge national response to the outbreak, its response to the crisis is also a lesson in how the country ’s political weak points can carry grave consequences for world health.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Coronavirus (2019-nCoV) China Politics and Government SARS (Severe Acute Respiratory Syndrome) Epidemics Xi Jinping Regulation and Deregulation of Industry Source Type: news
China's northern city of Tianjin will shut all inter-province shuttle buses from Jan. 27 in order to curb the coronavirus outbreak, the official People's Daily reported on Sunday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
China's central Hubei province, at the center of the Wuhan coronavirus outbreak, reported 13 new deaths caused by the new virus on Jan. 25, state media CCTV reported on Sunday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
As the coronavirus outbreak spreads, experts scramble to understand the origins and risk of the disease.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
China has confirmed 1,975 cases of patients infected with the new coronavirus as of Jan. 25, while the death toll from the virus has risen to 56, state media CCTV reported on Sunday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Anxiety is rippling across the globe as Beijing attempts to contain the growing outbreak.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
"The U.S. embassy in China is evacuating American citizens from Wuhan, the city at the center of the Coronavirus outbreak. More than 1,300 cases have been reported in the country and at least 41 people have died. In the U.S., 63 patients have been tested in 22 states. Ramy Inocencio reports.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Learning Objectives >>Learn about the possible causes of emergences and re-emergences of infectious diseases and how diseases spread. >>Understand when to have a high index of suspicion for enterovirus D68, which can present with many different signs and symptoms. >>Identify ways EMS systems can adapt during an outbreak to ensure provider safety while also still protecting and treating the community. Key Terms >>Emerging disease: A disease not previously recognized. >>Fomites: Any objects, including an EMS worker’s uniform, that can be contaminated by infectious pathogens and can play a ...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Infectious Diseases Patient Care Source Type: news
More News: African Health | Enterovirus | Genetics | Outbreaks | Respiratory Medicine | Tropical Medicine | Zoonoses