In vitro immune function in laboratory-reared age-0 smallmouth bass (Micropterus dolomieu) relative to diet

We report the results from a study evaluating a commercially available artificial pelleted diet for bass and live feed (fathead minnows). Following a six-month diet-acclimation period, age-0 smallmouth bass were assessed using morphometric measures, histologic and immune-function end points using conventional methods, miniaturized cell isolation and assay methods as well as imaging flow cytometry. Fish on the two diets did not significantly differ in length, weight, or condition factor, indicating that growth was similar in the two groups. Histologic examination revealed relatively higher levels of macrophage aggregates and accumulation of ceroid/lipofuscin in the spleen as well as hepatocyte changes in the pellet-fed group. Leukocytes from the pellet-fed group exhibited significantly elevated bactericidal activity and significantly depressed mitogen response compared to fish fed live feed. Following exposure to a known inducer of inflammatory responses, bacterial lipopolysaccharide, responses including the transition of leukocytes to an apoptotic/necrotic condition differed significantly based on diet. Histologic findings were consistent with the occurrence of diet-related oxidative stress in the pellet-fed fish. Oxidative stress can be induced by multiple factors including environmental pollutants. For a diet to be useful in laboratory-based studies, it cannot elicit response that could also be induced by experimental treatments. To do so greatly complicates the detection o...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research

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Conclusions: We found that perceived stigma in health care settings was a potential barrier to good health. Prior studies have illustrated that negative health outcomes are common for patients who avoid or delay care; thus, the unfortunate conclusion is that even in a diverse, heterogeneous community, stigma persists and may negatively affect well-being. Therefore, eliminating stigma in clinical settings should be a top priority for health care providers and public health professionals seeking to improve health equity.
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
Would having diagnosed anxiety or depression affect chances of getting into medical school if the school finds out an applicant has such problems?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
You're reading 7 Ways to Find Peace of Mind and Inner Calm, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. All our life, we keep on seeking the peace of mind but it is important to understand that it is not something we can buy or seek. We often get indulged in the process of seeking peace rather than attaining it. Happiness or peace is not something we can grasp, it comes from within. Yes, of course, we can try to meet people we love or buy things we like but peace is not just confined to materialistic pleasure. In...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured happiness meditation calm inner peace self improvement Source Type: blogs
ConclusionsThis underlines the importance of prevention and treatment for neuropsychiatric symptoms in ICU survivors in general, not only in specific patient groups.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
The objective of this study was to evaluate associations between marijuana use and the prevalence, severity, and rate of occurrence of tinnitus.Study designCross-sectional analysis of nationally representative data.SettingNational Health and Nutrition Examination Survey 2011–2012.Subjects and methodsStatistical analysis was performed on data collected from 2705 non-institutionalized adults aged 20–69 who underwent audiometric testing and were administered questionnaires about hearing, drug use, current health status, and medical history.ResultsThe use of marijuana at least once per month for the previous 12 m...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Publication date: Available online 13 November 2019Source: American Heart JournalAuthor(s): Geoffrey H Tofler, Marie-Christine Morel-Kopp, Monica Spinaze, Jill Dent, Christopher Ward, Sharon McKinley, Anastasia S Mihailidou, Jennifer Havyatt, Victoria Whitfield, Roger Bartrop, Judith Fethney, Holly G Prigerson, Thomas BuckleyBackgroundBereavement is associated with an increased risk of cardiovascular disease; however, no reports exist of interventions to reduce risk. In a randomized, double-blind, placebo-controlled trial of 85 recently bereaved participants, we determined whether beta-blocker (metoprolol 25 mg) and aspiri...
Source: American Heart Journal - Category: Cardiology Source Type: research
Brain stimulation therapies are important and effective treatments for people with depression and other mental disorders. The National Institute of Mental Health (NIMH) is supporting studies exploring how to make brain stimulation therapies more personalized and effective while reducing side effects.
Source: National Institute of Mental Health - Category: Psychiatry Authors: Source Type: news
Publication date: 12 November 2019Source: Cell Reports, Volume 29, Issue 7Author(s): Matthew E. Klein, Thomas J. Younts, Carmen Freire Cobo, Adina R. Buxbaum, Jonathan Aow, Hediye Erdjument-Bromage, Stéphane Richard, Roberto Malinow, Thomas A. Neubert, Robert H. Singer, Pablo E. Castillo, Bryen A. JordanSummaryThe transport and translation of dendritic mRNAs by RNA-binding proteins (RBPs) allows for spatially restricted gene expression in neuronal processes. Although local translation in neuronal dendrites is now well documented, there is little evidence for corresponding effects on local synaptic function. Here, we...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Isabella R. Grifasi, William Andrew Evans, Annie D. Rexha, Lansana W. Sako, S. Alex MarshallAbstractAlcoholism is a highly visible and prevalent issue in the United States. Although binge-drinking is assumed to be a college-age problem, older adults (ages 65 +) consume binge amounts of alcohol and have alcohol use disorders (AUDs). Moreover, individuals with alcohol dependence in their youth often continue to drink as they age. As such, this study tested the hypothesis that the effects of alcohol on hippocampal microglia are exace...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: 2019Source: International Review of Neurobiology, Volume 148Author(s): Katherine M. Keyes, Kasim Allel, Ursula M. Staudinger, Katherine A. Ornstein, Esteban CalvoAbstractAlcohol consumption is increasing in many countries, and excessive alcohol consumption is particularly increasing among older adults. Excessive alcohol consumption causes morbidity and mortality, especially among older adults, including an increased risk of depressive episodes. We review the mechanisms through which alcohol consumption may affect depression, and argue that the effects of alcohol consumption on depressive episodes among ol...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
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