On the performance of multivariate curve resolution to resolve highly complex liquid chromatography–full scan mass spectrometry data for quantification of selected immunosuppressants in blood and water samples

Publication date: Available online 15 October 2019Source: Microchemical JournalAuthor(s): Mahsa N. Sheikholeslami, Maryam Vosough, Hadi M. EsfahaniAbstractLiquid chromatography triple-quadrupole mass spectrometry (LC–MS/MS) in multiple reaction monitoring (MRM) mode is a commonly used approach for quantification of target compounds in complex samples. Regarding the multivariate advantages that can be obtained in the light of full spectra recording, the potential and performance of a smart strategy which is a post-processing of LC-MS full scan data sets with multivariate curve resolution-alternating least squares (MCR-ALS) algorithm for determination of cyclosporine-A (CsA) and tacrolimus (TAC) as typical immunosuppressants in human blood and organic micropollutants in surface water samples was investigated in the current study. Before peak resolution and quantification, LC-MS data compression was performed on each individual and augmented data matrices based on searching the regions of interest (ROIs) in the m/z domain. Then, due to presence of matrix effect, MCR-ALS modeling was performed using a matrix-matched calibration strategy. Here, the serious LC-MS issues such as background drift, chromatographic shifts and co-elution of non-calibrated sample constituents were resolved by implementation of MCR-ALS method on ROI based compressed data. It was shown that the strategy is a powerful tool for the quantitation of CsA and TAC in complex matrices and in the presence of ...
Source: Microchemical Journal - Category: Chemistry Source Type: research

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ConclusionsOur study showed that machine learning-based multiparametric MR imaging radiomics could accurately distinguish aggressive from non-aggressive PTC preoperatively. This approach may be helpful for informing treatment strategies and prognosis of patients with aggressive PTC.
Source: European Journal of Radiology - Category: Radiology Source Type: research
The Bombay High Court this week ordered the city government of Mumbai to pay...Read more on AuntMinnie.comRelated Reading: Deadly MRI accident heads to court in India Officials release fingers to family of Mumbai MRI victim Attendant to be charged in Mumbai MRI accident Mumbai MRI scanner back online after tragedy Report: Hospital staff members in fatal MRI case await charges
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Authors: Mumu SJ, Fahey PP, Ali L, Rahman AKMF, Merom D Abstract While the effect of weather and seasons on physical activity (PA) is well documented for leisure-time physical activities in western countries, scant information is available for developing countries where lifestyle PA is the major source of energy expenditure (EE). In Bangladesh, the traditional calendar divides the year to six seasons that last two months each: summer, rainy, autumn, late autumn, winter, and spring. We developed the Past Year Physical Activity Questionnaire to record culturally relevant physical activities and to help assess the sea...
Source: Journal of Environmental and Public Health - Category: Environmental Health Tags: J Environ Public Health Source Type: research
Conditions:   Metastases to Bone;   Metastatic Breast Cancer;   Metastatic NSCLC Intervention:   Other: Evaluation of the fracture risk using data from routine qCT (quantitative Computed Tomography) scan and numerical simulation Sponsor:   Hospices Civils de Lyon Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsIn vitro, intraoral scanners have shown acceptable accuracy. The main parameters identified for their influence on precision were interimplant distance, body scan design, scanning pattern, and operator experience. Clinical evidence is limited by the lack of a definitive method of assessing the fit of the framework.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
ConclusionCAC scores collected simultaneously with MPI improve the detection of obstructive coronary artery disease in patients without a history of coronary revascularization.
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Authors: John F, Robinette NL, Amit-Yousif AJ, Bosnyák E, Barger GR, Shah KD, Mittal S, Juhász C Abstract BACKGROUND: Clinical glioblastoma treatment mostly focuses on the contrast-enhancing tumor mass. Amino acid positron emission tomography (PET) can detect additional, nonenhancing glioblastoma-infiltrated brain regions that are difficult to distinguish on conventional magnetic resonance imaging (MRI). We combined MRI with perfusion imaging and amino acid PET to evaluate such nonenhancing glioblastoma regions. METHODS: Structural MRI, relative cerebral blood volume (rCBV) maps from perfusion MRI...
Source: Molecular Imaging - Category: Radiology Tags: Mol Imaging Source Type: research
Publication date: Available online 20 November 2019Source: Materials Today CommunicationsAuthor(s): Xiaojiao Li, Andreas Janke, Peter Formanek, Andreas Fery, Manfred Stamm, Bijay P. TripathiAbstractHighly hydrophilic and fouling-resistant polysulfone (PSF)-silica based nanocomposite ultrafiltration membranes were prepared using a one-pot method by combining phase inversion and nanoparticle formation in one step. The membrane forming solution prepared by mixing different amounts of tetraethyl orthosilicate (TEOS) with PSF solution in N-methyl-2-pyrrolidone (NMP) was cast on non-woven support and immersed into an aqueous aci...
Source: Materials Today Communications - Category: Materials Science Source Type: research
Publication date: Available online 20 November 2019Source: Materials Research BulletinAuthor(s): R. Kumar, I. Singh, R. Meena, K. Asokan, Balaji Birajdar, S. PatnaikAbstractLead-free Ba1−zLazTi0.95Sn0.05O3 with z=0.00, 0.015, 0.025, and 0.035 samples were prepared using solid-state reaction route. X-ray diffraction measurement reveals the single phase formation of ceramic samples. Scanning electron microscopy shows the inhibited grain growth (≤0.5 μm) at low La-doping while the higher La-doping in BTS ceramics yielded the larger grain size (2.5 μm). Raman spectra indicate the substitution of La at ...
Source: Materials Research Bulletin - Category: Materials Science Source Type: research
Publication date: 19 November 2019Source: Cell Reports, Volume 29, Issue 8Author(s): Dorit Kliemann, Ralph Adolphs, J. Michael Tyszka, Bruce Fischl, B.T. Thomas Yeo, Remya Nair, Julien Dubois, Lynn K. PaulSummaryA reliable set of functional brain networks is found in healthy people and thought to underlie our cognition, emotion, and behavior. Here, we investigated these networks by quantifying intrinsic functional connectivity in six individuals who had undergone surgical removal of one hemisphere. Hemispherectomy subjects and healthy controls were scanned with identical parameters on the same scanner and compared to a lar...
Source: Cell Reports - Category: Cytology Source Type: research
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